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Cerubidine - Daunorubicin

Cerubidine - daunorubicin Lysodren - mitotane Tegison - etretinate... [Pg.395]

The mechanism of action of daunorubicin and the indications for use are exactly the same as those of doxorubicin. Synonyms of this drug are daunoblastina, rabomycin, and cerubidine. [Pg.404]

The anthracycline antibiotics are fermentation products of Streptomyces peucetius. Daunorubicin (Cerubidine) is used to treat acute leukemias, while its structural analogue, doxorubicin (Adriamycin) is extensively employed against a broad spectrum of cancers. Although... [Pg.646]

Daunorubicin Cerubidine, DaunoXome Several forms of acute leukemia Blood disorders [anemia, leukopenia, thrombocytopenia] cardiotoxicity [arrhythmias, congestive heart failure] Gl distress [nausea, vomiting, Gl tract ulceration] hair loss... [Pg.574]

Daunorubicin (Daunomycin and Cerubidine) and doxorubicin (Adriamycin) bind to and cause the intercalation of the DNA molecule, thereby inhibiting DNA template function. They also provoke DNA chain scission and chromosomal damage. Daunorubicin is useful in treating patients with acute lymphocytic or acute granulocytic leukemia. Adriamycin is useful in cases of solid tumors such as sarcoma, metastatic breast cancer, and thyroid cancer. These agents cause stomatitis, alopecia, myelosuppression, and cardiac abnormalities ranging from arrhythmias to cardiomyopathy. [Pg.116]

Daunorubicin (Daunomycin and Cerubidine) and doxorubicin (Adriamycin) bind to and cause the intercalation of the DNA molecule, thereby inhibiting DNA template function. They also provoke DNA chain scission and chromosomal damage. [Pg.580]

Topoisomerase II inhibitors Daunorubicin (Daunomycin, Dauno, Cerubidine)"-Liposomal daunorubicin (DaunoXome)... [Pg.2303]

Streptomyces coerulerubidos yielded a tetracyclic aminosugar containing an antibiotic named daunorubicin (rubidomycin, Cerubidine ), which exhibited actinomycinlike antitumor activity. Severe cardiotoxicity, however, limited its clinical use, particularly as single agent therapy. [Pg.126]

Daunorubicin (daunomycin, rubidomycin Cerubidine, others) is available for intravenous use. The recommended dosage is 30 to 60 mg/m daily for 3 days. The agent is administered with appropriate care to prevent extravasation, as severe local vesicant action may result. Total doses greater than 1000 mg/m are associated with a high risk of cardiotoxicity. A daunorubicin citrate liposomal product (Daunoxome) is indicated in the treatment of AIDS-related Kaposi s sarcoma. It is given in a dose of 40 mg/m infused over 60 minutes and repeated every 2 weeks. Patients should be advised that the drug may impart a red color to the urine. [Pg.187]

See other pages where Cerubidine - Daunorubicin is mentioned: [Pg.37]    [Pg.1683]    [Pg.1683]    [Pg.354]    [Pg.37]    [Pg.355]    [Pg.642]    [Pg.1683]    [Pg.1683]    [Pg.37]    [Pg.585]    [Pg.37]    [Pg.1683]    [Pg.1683]    [Pg.354]    [Pg.37]    [Pg.355]    [Pg.642]    [Pg.1683]    [Pg.1683]    [Pg.37]    [Pg.585]    [Pg.185]    [Pg.127]    [Pg.639]    [Pg.127]    [Pg.372]    [Pg.415]    [Pg.397]    [Pg.91]    [Pg.646]    [Pg.187]    [Pg.127]    [Pg.588]    [Pg.298]   
See also in sourсe #XX -- [ Pg.37 ]

See also in sourсe #XX -- [ Pg.37 ]



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Cerubidin

Cerubidin - Daunorubicin

Daunorubicin

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