Cerebrospinal fluid magnesium

C. Pyrazinamide is known to cause hyperuricemia and precipitate gouty arthritis. Pyrazinamide-induced gouty arthritis does not respond to uricosuric therapy with probenecid but may respond to acetylsalicylic acid. Cycloserine (A) can cause headaches, confusion, tremors, and seizures, possibly secondary to low levels of magnesium in the cerebrospinal fluid cycloserine should be avoided in patients with epilepsy and mental depression. It is not associated with hyperuricemia. Thiacetazone (B) is an antibiotic that is rarely used in tuberculosis. The most common adverse reactions are general rashes and GI intolerance. Its use is not associated with hy-... 

The major concern of the emergency department physicians was the lethargy, hypotonia, and seizure activity. Initial laboratory studies revealed that the child had a normal complete blood count and smear. Other blood tests revealed metabolic acidosis with a bicarbonate concentration of 11 mEq/L (normal is 20-25 mEq/L) and an anion gap of 22 mEq/L (normal is < 15 mEq/L). His serum glucose, calcium, and magnesium concentrations were normal. To exclude the diagnosis of meningitis, a spinal tap was performed. The cell counts and chemistries of the cerebrospinal fluid were normal. The physicians considered that the child might have sepsis and administered antibiotics and intravenous fluids. Prior to administration of antibiotics, blood, urine, and cerebrospinal fluid were sent for bacterial culture. 

Horn and Latner (H6) analyzed blood and urine, using an air-propane flame. No interferences were encountered from other serum constituents. The fuel mixture of the flame was found to be critical. Decker et al. (D13) also include data on magnesium in cerebrospinal fluid. 

D13. Decker, C. F., Aras, A., and Decker, L. E., Determination of calcium and magnesium in human cerebrospinal fluid by atomic absorption spectroscopy. Abstr. Am. Chem. Soc., Div. Biol. Chem., Dec. 1963 p. 7A. 

CCS, Glasgow Coma Scale BP, blood pressure HR, heart rate RR, respiratory rate CSF, cerebrospinal fluid TBI, traumatic brain injury ICP, intracranial pressure CPP, cerebral perfusion pressure ABC, arterial blood gas CBC, complete blood count Na, sodium K, potassium Cl, chloride Mg, magnesium Ca, calcium P, phosphorus CT, computed tomography. 

J. L. Burguera, M. Burguera, and O. M. Alarcdn, Determination of Sodium, Potassium, Calcium, Magnesium, Iron, Copper and Zinc in Cerebrospinal Fluid by Flow Injection Atomic Absorption Spectrometry. J. Anal. Atom. Spectrom., 1 (1986) 79. 

Concentration of calcium and magnesium and trace elements (zinc, cooper, iron and manganeso) in cerebrospinal fluid A try of a pathophysiological classification /, Trace Elements Med. Biol. 2011 25 Supl. S45-S49. 

Voss LJ, Sleigh JW (2010) Stability of brain neocortical slice seizure-like activity during low-magnesium exposure measurement and effect of artificial cerebrospinal fluid temperature. J Neurosci Methods 192 214-218... 

Ammonium ion Creatinine Calcium Hemoglobin HDL cholesterol Magnesium(II) Phosphate (inorganic) Albumin Protein in cerebrospinal fluid ... 

Typical biological fluids include blood and blood serum, blood plasma, urine and saliva. Measurement of calcium in serum was the first analysis to which the technique of AAS was applied and is an obvious example of how FAAS is useful for biomedical analysis. Other specimens e.g. dialysis fluids, intestinal contents, total parenteral nutrition solutions, may be analysed on rare occasions. Elements present at a sufficiently high concentration are lithium and gold when used to treat depression and rheumatoid arthritis respectively, and calcium, magnesium, iron, copper and zinc. Sodium and potassium can be determined by FAAS but are more usually measured by flame atomic emission spectroscopy or with ion selective electrodes. Other elements are present in fluids at too low a concentration to be measured by conventional FAAS with pneumatic nebulization. With other fluids, e.g. seminal plasma, cerebrospinal fluid, analysis may just be possible for a very few elements. 

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