Central nervous system neurological diseases

Gullapalli D, Phillips LH, II (2004). Neurosarcoidosis. Current Neurology and Neuroscience Reports 4 441-447 Hankey GJ (1991). Isolated angiitis/angiopathy of the central nervous system. Cerebrovascular Diseases 1 2-15 Harrison CN, Linch DC, Machin SJ (1998). Desirability and problems of early diagnosis of essential thrombocythemia. Lancet 351 846-847... 

Ocular involvement relates primarily to the vascular inflammatory aspect of the disease. In the central nervous system the disease manifests itself as neurologic deficits and in the retina, as typical vaso-occlusive episodes. 

Another problem facing the diagnosis of depression or mania is the fact that other medical conditions can cause similar symptoms. Among them are illnesses such as thyroid diseases, infectious diseases (the flu), cancers of the central nervous system, neurological disorders (multiple sclerosis), blood diseases, and even some reactions to metal toxicity. 

Neurologic effects Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, have been reported in patients treated with nitroimidazole drugs including tinidazole and metronidazole. The appearance of abnormal neurologic signs demands the prompt discontinuation of tinidazole therapy. Administer tinidazole with caution to patients with central nervous system diseases. 

Complexity of inhibition of PLP-dependent enzymes is highlighted by detailed investigations on the inhibition of y-aminobutyric acid aminotransferase (GABA-AT), the enzyme responsible for the degradation of y-aminobutyric acid (GABA), one of the major inhibitory neurotransmitters in the mammalian central nervous system. Inhibition of GAB A-AT results in an increased concentration of GABA in the brain and could have therapeutic applications in neurological disorders (epilepsy, Parkinson disease, and Alzheimer disease). 

Chapter VIII - The central nervous system (CNS) elicits limited capacity to recover from injury. Though considerable efforts and means have been deployed to find treatments for neurological diseases, disorders and injuries, there is still no cure for these ailments, and new alternatives for therapy must be explored. Because they generate the main phenotypes of the nervous system, neural stem cells (NSCs) hold the promise to cure a broad range of neurological diseases and injuries. With the confirmation that neurogenesis occurs in the adult... 

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