Cellular objectives

Foam molding operations are those in which a liquid mixture of foam components is poured into a cavity to form a cellular object or shape. The molded item is later removed after setting or curing. In the case of expandable polystyrene beads the pre-expanded or virgin beads are poured into a mold and heated to form the desired object. In this case, liquids are not used, although the free-flowing beads might be considered as a "fluid."... 

Each of our proteins evolved along with the structures that are reproducing it and along with the mobile cell membranes and sub-cellular objects that it must, from its birth to its death, exist with. 

Keywords Cellular objectives Directed evolution Diversity Engineering objectives Evolutionary engineering Fimess landscapes Industrial microbiology Screening and selection... 

When considering the fimess landscape, the highest fimess is related to me phenotypic function wim respect to a specific objective. In terms of EvoEng, mere are normally two different objectives mat often are at odds wim each omer, a cellular objective (e.g. growm) and an engineering objective (e.g. production of a target chanical). 

Molded cellular objects Acrylamide Acrylic acid Britain 1,204,608 1970 Rohm Haas ... 

Ion Channels. The excitable cell maintains an asymmetric distribution across both the plasma membrane, defining the extracellular and intracellular environments, as well as the intracellular membranes which define the cellular organelles. This maintained a symmetric distribution of ions serves two principal objectives. It contributes to the generation and maintenance of a potential gradient and the subsequent generation of electrical currents following appropriate stimulation. Moreover, it permits the ions themselves to serve as cellular messengers to link membrane excitation and cellular... 

A surface is that part of an object which is in direct contact with its environment and hence, is most affected by it. The surface properties of solid organic polymers have a strong impact on many, if not most, of their apphcations. The properties and structure of these surfaces are, therefore, of utmost importance. The chemical stmcture and thermodynamic state of polymer surfaces are important factors that determine many of their practical characteristics. Examples of properties affected by polymer surface stmcture include adhesion, wettability, friction, coatability, permeability, dyeabil-ity, gloss, corrosion, surface electrostatic charging, cellular recognition, and biocompatibility. Interfacial characteristics of polymer systems control the domain size and the stability of polymer-polymer dispersions, adhesive strength of laminates and composites, cohesive strength of polymer blends, mechanical properties of adhesive joints, etc. 

A cure in oncology implies that the cancer is completely gone, and the patient will have the same life expectancy as a patient without cancer. A complete response (CR) refers to complete disappearance of all cancer for 1 month after treatment. A partial response (PR) is defined as a 50% decrease in tumor diameter along with no new disease for 1 month. The term overall objective response rate refers to the combination of PR and CR. Stable disease refers to tumor that has not grown and has shrunk by less than 25% of the diameter. Disease progression refers to tumor that has spread or the primary tumor has increased in size by 25%. Some cancers, such as leukemia, cannot be measured by size, so biopsy of the bone marrow provides a cellular indication of absence or presence of disease. 

Dosimetric Studies. The main objective of Rn-d dosimetry is to enable the assessment of the observed dose from Rn-d deposited in the respiratory tract from measured Rn-d concentration in the atmosphere. As a consequence of an inhomogeneous Rn-d deposition within the lung, different dosimetric concepts have been developed to describe either regional mean dose values (e.g. for tracheobronchial or pulmonary region) or microdosimetric dose calculations (e.g. for the basal cell layer). Using Monte Carlo calculation methods it is also possible to account for the random nature of cellular hits by deposited alpha particles. The results of such dosimetric calculations should provide the following information needed for Rn-d risk assessment ... 

The slow intrinsic GTP-hydrolysis by Ras can be accelerated by orders of magnitudes upon interaction with its GTPase activating proteins (GAPs). The cytosolic RasGAPs pl20RasGAP and NF1 (neurofibromin) are the main factors, which ensure that cellular Ras exists predominantly in its inactive GDP-complexed state [26]. The mechanism of GTP-hydrolysis and its stimulation has been the object of controversial disputes for over a decade. 

Efficacy. A relative concept referring to the ability of a medicine to elicit a beneficial clinical effect. This may be measured or evaluated using objective or subjective parameters, and in terms ranging form global impressions to highly precise measurements. Efficacy is assessed at one or more levels of organization (e.g., subcellular, cellular, tissue, organ, whole body) and may be extrapolated to other levels. 

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