Cellular biochemistry

Disease States. Rickets is the most common disease associated with vitamin D deficiency. Many other disease states have been shown to be related to vitamin D. These can iavolve a lack of the vitamin, deficient synthesis of the metaboUtes from the vitamin, deficient control mechanisms, or defective organ receptors. The control of calcium and phosphoms is essential ia the maintenance of normal cellular biochemistry, eg, muscle contraction, nerve conduction, and enzyme function. The vitamin D metaboUtes also have a function ia cell proliferation. They iateract with other factors and receptors to regulate gene transcription. 

Marlowe, J.L. and Puga, A. (2005). Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. Journal of Cellular Biochemistry 96, 1174-1184. 

Carmen Socaciu was bom in Cluj-Napoca, Romania and earned a BSc in chemistry in 1976, an MSc in 1977, and a PhD in 1986 from the University Babes-Bolyai in Cluj-Napoca, an important academic centre located in the Transylvania region. Dr. Socaciu worked as a researcher in medical and cellular biochemistry for more than 10 years, and became a lecturer in 1990 and full professor in 1998 in the Department of Chemistry and Biochemistry of the University of Agricultural Sciences and Veterinary Medicine (USAMV) in Cluj-Napoca. She extended her academic background in pure chemistry (synthesis and instrumental analysis) to the life sciences (agrifood chemistry and cellular biochemistry). Her fields of competence are directed especially toward natural bioactive phytochemicals (carotenoids, phenolics, flavonoids), looking to advanced methods of extraction and analysis and to their in vitro actions on cellular metabolism, their effects as functional food ingredients, and their impacts on health. 

Gross GJ and Lockwood SF. 2005. Acute and chronic administration of disodium disuccinate astaxanthin (Cardax ) produces marked cardioprotection in dog hearts. Molecular and Cellular Biochemistry 272(1-2) 221-227. 

Gross GJ, Hazen SL, and Lockwood SF. 2006. Seven day oral supplementation with Cardax (disodium disuccinate astaxanthin) provides signihcant cardioprotection and reduces oxidative stress in rats. Molecular and Cellular Biochemistry 283(1-2) 23-30. 

Center for Structural Biology, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536... 

Simpson, MA, LiCata, V.J., Coe, N.R. and Bernlohr, D.A. (1999) Biochemical and biophysical analysis of the intracellular lipid binding proteins of adipocytes. Molecular and Cellular Biochemistry 192, 33—40. 

Jimenez, B., del Peso, L., Montaner, S., Esteve, P. and Lacal,J.C. (1995) Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation. Journal of Cellular Biochemistry 57, 141—149. 

The intracellular environment of eukaryote cells can be subdivided into many regions, including the organelles, nucleus, cytoplasm and the cell periphery. Thus solutes must be delivered to the right intracellular compartment at the correct time to efficiently serve cellular biochemistry. Uncharged solutes such as glucose presumably diffuse across the cell, and the traditional view held until recently was that the major electrolytes, such as Na+,K+,CF and Mg2+, also move around the cell by simple diffusion to eventually arrive at the relevant subcellular compartment by chance. 

Ahmed, S.S., Napoli, K.L. and Strobel, H. W. (1995) Oxygen radical formation during cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations. Molecular and Cellular Biochemistry, 151 (2),... 

Hallett, M. B., ed. (1989). The Neutrophil Cellular Biochemistry and Physiology. CRC Press, Boca Raton, Fla. 

Sheterline, P., Rickard, J. E. (1989). The cortical actin filament network of neutrophil leucocytes during phagocytosis and chemotaxis. In The Neutrophil Cellular Biochemistry and Physiology (Hallett, M. B., ed.), pp. 141-65, CRC Press, Boca Raton, Fla. 

Early American Studies on Respiration Calorimetry. (With Jerry F Janssen). Molecular and Cellular Biochemistry, 5, 11-16 (1974)... 

Howard Hughes Medical Institute Memorial Sloan-Kettering Cancer Center Cellular Biochemistry and Biophysics Program 1275 York Avenue New York, NY 10021 USA... 

Cellular Biochemistry Section, Department of Nutrition and Health Sciences. Siebold University of Nagasaki, Nagayo, Japan Institute of Applied Biochemistry. Vagi Memorial Park, Mitake, Giu, Japan... 

This series is a continuation of the journal Sub-Cellular Biochemistry. Volume 1 to 4 of which were published quarterly from 1972 to 1975... 

Freitas, M.A., Sklenar, A.R. and Parthun, M.R. (2004) Application of mass spectrometry to the identification and quantification of histone post-translational modifications. Journal of Cellular Biochemistry, 92, 691—700. 

Musavi S. and P. Kakker (2003). Effect of diazepam treatment and its withdrawal on pro/anti-oxidative in rat brain. Molecular and Cellular Biochemistry 245 51-56. 

Farber, E. (1984). Cellular biochemistry of the stepwise development of cancer with chemicals G.H.A. Clowes Memorial Lecture, Cancer Res. 44, 5463. 

Chayen, J., Howat, D.W., Bitensky, L. (1986) Cellular biochemistry of glucose 6-phosphate and 6-phosphogluconate dehydrogenase activities. Cell Biochem. Fund. 4, 249-253. 

We hope this review and the series in general have drawn attention to the almost incredible advances in biochemical knowledge during the past fifty years. But it is now goodbye to Bio-chemistry and welcome to Molecular and Cellular Biochemistry. 

Fig. 18.2. Raman spectroscopy of live, fixed and dried cells. Raman spectrum of a single cell construct provides a unique biochemical fingerprint , which provides a snap shot of the entire biomolecular components. The mean Raman spectra (4 separate measurements) of a single live, fixed and desiccated epithelial cell are compared (a). Fixation and desiccation influence cellular biochemistry. Desiccation distorts Raman bands describing all cellular biopolymers, especially proteins. Distinct biochemical changes in the secondary structure of proteins in the fixed cell can also be detected. Similar results were obtained in several other cells when analysed under similar conditions. Light microscope pictures of the cells in live cell culture (b), and after fixation (c) and desiccation (d) are shown. Scalebar = 10 pm. [3]...

Huang, C Li, J., Ding, M. et al. (2001) Arsenic-induced NFB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells. Molecular and Cellular Biochemistry, 222(1-2), 29-34. 

Akhlaq Farooqui Department of Molecular and Cellular Biochemistry The Ohio State University 3120 Herrick Road Columbus, Ohio USA... 

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