Cell-surface carbohydrate recognition

Weis, W. 1. (1997). Cell-surface carbohydrate recognition by animal and viral lectins. Curr. Opin. Struct. Biol. 7, 624-630. 

Direct application of the technique to the study of cell surface carbohydrate recognition was realized later, mostly using sialic acids, as summarized in Section IV. 

General Considerations Cell-surface Carbohydrate Recognition Interactions 11.1.3.1 S-type Lectins, Galectins... 

Cell Surface Carbohydrate Recognition by Artificial Lectins - Boronoiectins S03... 

Cell Surface Carbohydrate Recognition by Artificiai Lectins - Boronolectins 1505... 

Brandley, B. H., and Schnaar, R. F. (1986). Cell-surface carbohydrates in cell recognition and response. J. Leukoc. Biol. 40, 97-111. 

Thorough, advanced treatment of the chemistry and biology of cell surface carbohydrates. Good chapters on lectins, carbohydrate recognition in cell-cell interactions, and chemical synthesis of oligosaccharides. 

Sialic acids are a family of nonulosonic acids that have been predominantly found as the outermost carbohydrate units on glycoproteins and glycolipids of vertebrates, or as components of polysaccharides in certain types of bacteria (I, 2). Sialic acids play vital roles in a variety of physiological and pathological processes in vertebrates, such as cellular recognition and communication (1, 2). They are also believed to be important virulence factors in bacteria, used by bacteria to mimic sialylated host cell surface carbohydrate structures to evade detection and attacking by the immune defense mechanisms of the host (3-6). 

A. J. Mort, Cell Surface Carbohydrates and Biological Recognition, Liss, New York, 1978, pp. 553-561. 

One important area of current research is on the recognition of carbohydrates. In particular, cell surface carbohydrates have implications in various disease states. In some forms of cancer, closely packed cell surface carbohydrates effect cancer progression and invasiveness. Many of these carbohydrates have terminal sialic acid groups. The pinwheel receptor 42 was designed as a divalent receptor for anionic sugars including sialic acid with a view toward making sensors for cancer markers. Sensor 42 used a boronic acid to bind a diol on the... 

Sharon, N., and H. Lis. Carbohydrates in Cell Recognition. Sd. Amer. 268 (1), 82-89 (1993). [The development of drugs to stop infection and inflammation by targeting cell-surface carbohydrates.]... 

The continued interest in this field of study is reflected in the large number of review articles which have been published. The proceedings of an ICN-UCLA Symposium, in Colorado in 1977, have been published under the title Cell Surfaee Carbohydrates and Biological Recognition , and the proceedings of another symposium on cell membranes of normal and neoplastic cells has appeared as Cell Surface Carbohydrate Chemistry . Cell-surface antigens, with special reference to the histocompatibility antigens, have been reviewed. A comprehensive survey of the metabolism of cell-surface components in both eukaryotic and prokaryotic cells has been published. Other reviews have... 

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