Cell death induction

Jak M, van Bochove GG, Reits EA et al (2011) CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type 11 anti-CD20 mAb GAIOI. Blood 118 5178-5188... 

Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apol, and DR3 and is lethal prenatally. Immunity 1998 9 267-276. 

Abstract Considering the presence of multiple types of cell death induced by chemicals, it is important to determine a definitive strategy for the exploration of new highly tumor-selective compounds. The screening of highly selective compounds should be performed before the identification of the type of cell death (either apoptosis, autophagy, or necrosis) and the cell death induction mechanism. The tumor specificities of heterocyclic compounds and the type of cell death induced by them are summarized. 

Varfolomeev E, Alicke B, Elliott JM et al (2009) X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. J Biol Chem 284 (50) 34553-34560... 

Moll UM, Marchenko N, Zhang X-K. p53 and Nur77/TR3-transcription factors that directly target mitochondria for cell death induction. Oncogene 2006 25 4725-4743. 

AIF may contribute to acute neuronal injury induced by trauma, hypoglycemia or transient ischemia as well as in chronic neurodegeneradve diseases (Table 3). The translocadon of AIF has been observed in different experimental models of neurotoxicity including death of photoreceptors induced by rednal detachment, neuronal cell death induct in vivo by brain trauma and cerebral ischemia and death of cortical neurons induced in vitro by exposure to... 

Loeffler M, Daugas E, Susin SA et al. Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J 2001 15(3) 758-67. 

Yang H, Zhou P, Huang H, Chen D, Ma N, Cui CQ, Shen S, Dong W, Zhang X, Lian W, Wang X, Dou QP, Liu J. Shikonin exerts antimmor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int J Cancer. 2009 124 2450-9. 

Fig. 10.7. Mechanisms of chemoradiation on a molecular level. The most prominent points of interaction of radiation with chemotherapy being of importance for the efficacy of a combined modality treatment are found on the level of DNA damage induction and repair, cell death induction, and cell cycle control...

Two studies have proposed that berberine induces cell death by the extrinsic pathway in human colon carcinoma [134] and human hepatoma [131] cell lines however, direct evidences of this mechanism were lacking. In neither of those studies, the role of Fas or FasL was tested if blocking the ligand or receptor could prevent cell death induction by berberine. 

The trypsin inhibitor from Peltophorum dubium seeds (PDTI), as well as soybean trypsin inhibitor (SBTI), both belonging to the Kunitz family, have lectin-like prop>erties and trigger rat lymphoma cell apoptosis. It was shown that PDTI and SBTI induce human leukemia Jurkat cell death. Induction of apoptosis was confirmed by flow cytometry (Troncoso et al., 2009). 

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