Cell Death During Lung Health and Disease

Imaging Cell Death During Lung Health and Disease 

Evidence for PARP-1 activation during lung disease also exists. For instance, shear forces associated with mechanical ventilation may result in alveolar epithelial cell necrosis, that is, mediated in part by PARP-1 activation (45). Likewise, PARP-1 activation has been implicated in the pathogenesis of septic shock, an important cause of acute lung injury (47). 

It is clear from these observations that more information about mechanisms of cell death during lung health and disease is needed. Most studies of apoptosis in the lungs, however, have been conducted in animal models. Evidence in humans is largely limited to tissue biopsy material and/or biochemical analysis of bronchoalveolar lavage fluid. Such studies are imperfect because of sampling limitations, both temporally (over time) and spatially (selection of sites for tissue 

Neuss M, Crow MT, Chesley A, Lakatta EG. Symposium programmed ceU death-cUnical reality and therapeutic strategies. Cardiovasc Drug and Ther 2001 15 507 523. 

Flotats A, Carrio I. Non-invasive in vivo imaging of myocardial apoptosis and necrosis. Eur J Nucl Med Biol 2003 30 615-630. 

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