Cell compatibility

S. Isik, L. Berdondini, J. Oni, A. Blochl, M. Koudelka-Hep, and W. Schuhmann, Cell-compatible array of three-dimensional tip electrodes for the detection of nitric oxide release. Biosens. Bioelectron. 20, 1566-1572 (2005). 

A further proof of principle was conducted by Cooney et al. who demonstrated the feasibility of the Andersen cascade impactor as a cell compatible deposition device [90], Permeability coefficients of fluorescent isothiocyanate-labeled dextrans after impaction as aerosols on Calu-3 cells were calculated. Deposition did not negatively affect the cell monolayer integrity. 

The conclusion drawn from the above-discussed features of native endothelium is that—where feasible—construction of host endothelium on the surface of synthetic implants—i.e. engineered endothelialization—may present a promising pathway for fundamentally resolving the biocompatibility and bio-functionality of artificial cardiovascular transplantation. This proposed biocompatibility is, however, not simply thromboresistance (or blood compatibility) plus blood-cell compatibility, but a real bioactive, self-renewable and specifically functional alliance of tissues and synthetics. 

A current goal is to establish long term biocompatibility of engineering and structural materials, especially for prosthetic devices, by promoting the rapid attachment and proliferation of living cells compatible with the site of ultimate implantation. Fine fabric meshes are of great utility in this application. The great sensitivity (and simplicity) of... 

CytocompatibUity is a key issue for membrane in bioartificial organs. In this respect, the development of new materials with physicochemical properties that provide improved blood/cell compatibility is strictly related to the progress in this promising... 

Armbruster C, Robibaro B, Griesmacher A, Vorbach H. Endothehal cell compatibility of trovafloxacin and levoflox-acin for intravenous use. J Antimicrob Chemother 2000 45(4) 533-5. 

This defines a set of equations for the mean field Hamiltonians HPF. These equations have to be solved self-consistently since the thermodynamic values within the angle brackets in (109) involve the mean field Hamiltonians // F. In principle, all // F can be different in practice, we impose symmetry relations. Therefore, we choose a unit cell, compatible with the symmetry of the lattice introduced in Section II,D, and we put Hpf equal to // F whenever P and P belong to the same sublattice. Moreover, we apply unit cell symmetry that relates the mean field Hamiltonians on different sublattices. By using the symmetry-adapted functions introduced in Section II,B, the latter symmetry can be imposed as follows. We select a set of molecules constituting the asymmetric part of the unit cell. Then we assign to all other molecules P Euler angles tip-through which the mean field. Hamiltonian of some molecule P in the asymmetric part has to be rotated in order to obtain HrF. As a result, we... 

Immobilization of heparin in the composite matrices (i.e., films and porous scaffolds) showed improved blood compatibility, as well as good mechanical properties and endothelial cell compatibility... 

Chitosan films with Neural cell Dependency of Cell compatibility Frier et al. 

The last column is a cummulative metric of polymer-cell compatibility on an arbritrary - -, -, +/-, +, -h+ scale. 

H J. Wang, L.W. Ji, D J. Li, and J.Y. Wang, Characterization of nanostructure and cell compat-ibdity of polyaniUne films with different dopant acids, J. Phys. Chem. B, 112,2671-2677 (2008). 

Polyurethane Methacrylic acid Enhanced hydrophilicity, enhanced biological cell compatibility [103]... 

For specific applications [e.g., bone tissue engineering], BC-gelatin/PA doped with hydroxyapatite [HAp] were synthesized [BC-gelatin/PA/Hap]. The cell compatibility of BC-gelatin/PA/HAp was tested with mesenchymal stem cells [58]. The results indicated that the composite supported cell growth and proliferation, over 7 days of cultivation. Studies on the effectiveness of composites in vitro and in vivo behavior should be further explored. 

R.A. Hoshi, R. Van Lith, M.C Jen, J.B. Allen, K.A. Lapidos, G. Ameer, The blood and vascular cell compatibility of heparin-modified ePTFE vascular grafts, Biomaterials 34 (2013) 30-41. 

Werner, J., Linner-Krcmar, B., Friessc, W., and Greil, P. (2002) Mechanical properties and in vitro cell compatibility of hydroxyapatite ceramics with graded pore structure, Biomaterials 23, 4285. 

In the following, we will focus on in vitro tests for cell compatibility and blood compatibility. In this context, we will also discuss ISO 10993-5 (tests for in vitro cytotoxicity) and ISO 10993-4 (selection of tests for interactions with blood). Finally, the risk of pyrogens in the biomaterial context, especially of bacterial toxins (endotoxins), will be briefly highhghted and selected methods for determining pyrogens/endotoxins (cf. also ISO 10993-11) will be presented. 

F1027 Assessment of tissue and cell compatibility of orofacial prosthetic materials and devices F1877 Characterization of particles... 

Seliktar D (2012) Designing cell-compatible hydrogels for biomedical applications. Science 336 1124-1128. doi 10.1126/science. 1214804... 

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