Stem cells committed progenitors

FIGURE 29-2 Stem cells undergo symmetric divisions to increase the pool size of stem cells, or asymmetric divisions to give rise to a committed progenitor cell and another stem cell. Committed progenitor cells may go on to differentiate immediately to directly replace mature cells lost in response to injury or disease. Alternatively, expansion factors may stimulate extensive division of a specific progenitor cell, and produce large numbers of a mature cell type. 

A cartoon depicting the interrelationships between stem cells, committed progenitor cells, and ISEMFs in the gastric mucosa. This is a bidirectional cross talk that allows the epithelium (and its environment) to affect the fate of stem cells via growth factors and the mesenchyme. 

The development of mature neutrophils in the bone marrow occurs via the differentiation of multipotential stem cells into progenitor cells that are committed to neutrophilic lineages. As this process proceeds the ability of... 

Stem cells give rise to committed progenitors 504 Lessons from the hematopoietic stem cell 505 Bone marrow stem cells may not be restricted to the blood cell lineage 506... 

Stem cells give rise to committed progenitors. In a... 

An important controversy remains about which factors, intrinsic or extrinsic, control the stem cell s decision to self-renew or develop into one of several committed progenitor cells. Two distinct models have been proposed to... 

Further evidence for a dynamic cardiac renewal process in the adult heart comes from the recent identification of a novel population of early tissue-committed stem cells that may be part of a group of circulating progenitor cells involved in cardiac repair [40]. 

On the fifth day, they undergo leukapheresis. The success of PBSC transplantation depends on transfusion of adequate numbers of stem cells. CD34, an antigen present on early progenitor cells and absent from later, committed, cells, is used... 

Umbilical cord blood is an alternative source of hemopoietic stem cells rather than bone marrow, especially for patients who lack an HLA-matched donor (35). Umbilical cord blood contains significantly more early and committed progenitor cells and has been used in patients with malignant and non-mahgnant hematological diseases. One of the advantages of cord blood is that it... 

The understanding of drug-indnced hematologic disorders requires a basic understanding of hematopoiesis (see Chap. 98 on hematopoiesis). The pluripotential hematopoietic stem cells in the bone marrow, which have the ability to self-reprodnce, maintain the blood. These pluripotential hematopoietic stem cells are further differentiated to intermediate precursor cells, which are also called progenitor cells or colony-forming cells. Committed to a particnlar cell line, these intermediate stem cells differentiate into colonies of each type of blood cell in response to a particular colony-stimulating factor (Fig. 102-1). 

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