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Celastrol

FIGURE 8.1 Inhibition of the NF-kB signaling pathway with celastrol 76. [Pg.283]

The inhibition of the phosphorylation of IkBoc by celastrol in the NF-kB signaling pathway is not cell specific72-75 and thus significantly broadened the potential medicinal applications of natural triterpene QMs. Celastrol 76 has been evaluated in the treatment of Crohn s disease,76 which is a chronic relapsing inflammatory bowel disease. In the peripheral blood mononuclear cells, celastrol 76 reduced the levels of... [Pg.283]

In the NF-kB pathway with celastrol 76, the inhibition of the iKBa degradation is due to the upstream blockage of the kinase activity and not by the direct inhibition of proteasome activity. On the contrary, direct inhibition of proteasome activity was observed with celastrol 76 and pristimerin 2 in prostate cancer cells.90-92 Both triterpene QMs directly inhibited the activity of the 20S subunits of proteasome at 2.5 iM and induced the accumulation of ubiquitinated proteins over time in cells,... [Pg.284]

Nagase, M. Oto, J. Sugiyama, S. Yube, K. Takaishi, Y. Sakato, N. Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci. Biotechnol. Biochem. 2003, 67, 1883-1887. [Pg.292]

Abbas, S. Bhoumik, A. Dahl, R. Vasile, S. Krajewski, S. Cosford,N. D. P. Ronai,Z. A. Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clin. Cancer Res. 2007, 13, 6769-6778. [Pg.292]

Sethi, G. Ahn, K. S. Pandey, M. K. Aggarwal, B. B. Celastrol, a novel triterpene potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting... [Pg.292]

Pinnaa, G. F. Fiorucci, M. Reimund, J.-M. Taquet, N. Arondel, Y. Muller, C. D. Celastrol inhibits pro-inflammatory cytokine secretion in Crohn s disease biopsies. Biochem. Biophys. Res. Commun. 2004, 322, 778-786. [Pg.293]

Jung, H. W. Chung, Y. S. Kim, Y. S. Park, Y.-K. Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kB in LPS-stimulated BV-2 microglial cells. Exp. Mol. Med. 2007, 39, 715-721. [Pg.293]

Cleren, C. Calingasan, N. Y. Chen, J. Beal, M. F. Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. J. Neurochem. 2005, 94, 995-1004. [Pg.293]

Chow, A. M. Brown, I. R. Induction of heat shock proteins in differentiated human and rodent neurons by celastrol. Cell Stress Chaperones 2007, 12, 237-244. [Pg.293]

Zhang, Y.-Q. Sarge, K. D. Celastrol inhibits polyglutamine aggregation and toxicity through induction of the heat shock response. J. Mol. Med 2007, 85, 1421-1428. [Pg.293]

Allison, A. C. Cacabelos, R. Lombardi, V. R. M. Alveraz, X. A. Vigo, C. Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer s disease Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2001, 25, 1341-1357. [Pg.293]

Sun, H. Liu, X. Xiong, Q. Shikano, S. Li, M. Chronic inhibition of cardiac Kir2.1 and hERG potassium channel by celastrol with dual effects on both ion conductivity and protein trafficking. J. Biol. Chem. 2006, 281, 5877-5884. [Pg.294]

Trott, A. West, J. D. Klaic, L. Westerheide, S. D. Silverman, R. B. Morimoto, R. I. Morano, K. A. Activation of heat shock and antioxidant responses by the natural product celastrol transcriptional signatures of a thiol-targeted molecule. Mol. Biol. Cell2008,19, 1104-1112. [Pg.296]

Tripterygium wilfordii Hook. f. Lei Gong Teng (Yellow vine) (root) Tripchilorolide, celastrol, triptein, wilfordine, triptophenolide, triptonide, triptolide, tripdiolide, triptolidenol, tripchlorolide, triptolide, tripdioltonide, trihydroxytriptolide, triptolide.33-241-390-431-443 This herb is toxic with adverse effects on gastrointestinal tract. Antifertility effect on male, anti-inflammatory, antitumor, treat cancer, antirheumatoid arthritis, suppressive effects. [Pg.165]

The roots of Ethiopian khat contain cathedulins E2, E3, E4, E5, and E6. The root bark itself is orange-red, and this was found to be caused by the presence of triterpenoid quinones (48). Those identified were celastrol (64), pristimerin (65),... [Pg.157]

Lactacystin, salinosporamide A, epoxomicin, dihydroeponemycin, EGCG,3,5-dicaffeoylquinic acid, apigenin, quercetin, celastrol, withaferin A... [Pg.660]

See other pages where Celastrol is mentioned: [Pg.350]    [Pg.280]    [Pg.280]    [Pg.281]    [Pg.282]    [Pg.282]    [Pg.283]    [Pg.284]    [Pg.284]    [Pg.285]    [Pg.288]    [Pg.292]    [Pg.293]    [Pg.294]    [Pg.154]    [Pg.269]    [Pg.402]    [Pg.78]    [Pg.350]    [Pg.664]    [Pg.757]    [Pg.758]   
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Celastrol structure

Celastrol type compounds

Tripterygium wilfordii celastrol from

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