Phenoxymethyl penicillin

Penicillin V—see Penicillin, phenoxymethyl-, 7, 300 Penicilloate, benzyl-, 7, 303 Penicilloate, D-a-benzyl-a-methyl ester, 7, 303 Penillamine, benzyl-, 7, 303 Penillic acid, benzyl-, 7, 303 Penilloaldehyde, benzyl-, 7, 303 Penilloic acid, benzyl-, 7, 303 Penillonic acid, benzyl-methyl ester, 7, 303 1,2,3,4,6-Pentaazaindene nomenclature, 1, 18 Pentadeca-5,10-dienols synthesis, 1, 428 Pentadienol, tetrachloro-2H-pyran synthesis from, 3, 740 Pentadienonitrile, 5-(l,2-benzoselenazol-3-yl)-X-ray diffraction, 6, 334 Penta-2,4-dienonitrile, 5-(dimethylamino)-2-(2-thienyl)-... 

The most commonly used source of penicillin V acylase is the fungus Bovista plumbia. Incubation of phenoxymethyl penicillin (penicillin V) with this enzyme produces a yield of about 90-92% 6-APA. 

Benzyl-, phenoxymethyl-and other penicillins N-Deacylation 6-APA and the corresponding acyl side chains Escherichia coli Fusarium semitectum Penidllium chrysogenum Aspergillus oryzae Nine different bacteria... 

The class C enzymes have Mr values of 39,000 and exhibit more uniform properties. They hydrolyse benzyl- and phenoxymethyl penicillin relatively well (turn-over numbers of 20-70 s-1), ampicillin and amoxicillin 10- to 20-fold less rapidly and extremely poorly the other penicillins (generally due to low k3 values). The early cephalosporins (cephalothin,... 

Oxidation of phenyl hexyl sulphide with sodium metaperiodate gave also only a trace amount of the corresponding sulphoxide72. On the other hand, Hall and coworkers73 prepared benzylpenicillin and phenoxymethyl penicillin sulphoxides from the corresponding benzyl esters by oxidation with sodium metaperiodate in dioxane solution with a phosphate buffer. A general procedure for the synthesis of penicillin sulphoxides was reported later by Essery and coworkers74 which consists in the direct oxidation of penicillins or their salts with sodium metaperiodate in aqueous solution at pH 6.5-7.0. 1-Butadienyl phenyl sulphoxide 4475 and a-phosphoryl sulphoxides 4576 were also prepared by the same procedure. 

AE Davis, RC Pirola. Absorption of phenoxymethyl penicillin in patients with steatorrhea. Aust Ann Med 17 63-65, 1968. 

Lennernas, H., Gjellan, K., Hallgren, R., Graffner, C., The influence of caprate on rectal absorption of phenoxymethyl-penicillin experience from an in-vivo perfusion in humans, J. Pharm. Pharmacol. 2002, 54, 499-508. 

Phenoxymethyl penicillin potassium, 7,249 Phenylephrine hydrochloride, 3,483 Piperazine estrone sulfate, 5, 375 Primidone, 2,409... 

Figure 2 Dissolution characteristics of potassium phenoxymethyl-penicillin pure drug and several formulations available on the German market according to the test conditions given in Table 3 (A) At acid pH (the pH used to generate the data shown here was pH 1.2 rather than pH 2 as indicated in the Table) and (B) at pH 6.8.

Phenoxymethyl penicillin sulfoxide methanol solvate S J. Am. Chem. Soc. 1969,97, 1408... 

Penicillins. This group includes penicillin G (benzyl-penicillin), penicillin VK (phenoxymethyl-penicillin), the isoxazolyl penicillins oxacillin, cloxacillin, dicloxacillin and nafcillin, the amino-penicillins ampicillin, hetacillin and amoxycillin, the carboxy-penicil-lin carbenicillin, and the thienyl-penicillin ticarcillin. 

IR spectrum of phenoxymethyl penicillin potassium. Obtained as a KBr disc. 

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