Cefixime activity

More active in vitro against Staphylococcus aureus and Enterococcus faecalis than cefixime, but less active against some Enterobacteriaceae. 

Cefixime is an orally active third-generation cephalosporin antibiotic which has marked in-vitro bactericidal activity against a wide variety of gram positive and negative organisms. It is indicated for the treatment of urinary tract, infection, respiratory tract infection and biliary tract infection etc. 

ANTICOAGULANTS-ORAL CEPHALOSPORINS Certain cephalosporins (cefaclor, cefixime, ceftriaxone) may t efficacy of oral anticoagulants These cephalosporins have vitamin K antagonistic activity, which adds to the action of oral anticoagulants. Monitor INR closely any significant t INR may require vitamin K therapy. If possible, use an alternative cephalosporin... 

Gram-negative Neisseria gonorrhoeae is within the spectrum of activity for penicillin G, but many strains of this organism produce penicillinase. Because antibiotic therapy is typically taken before bacterial susceptibilities are known, recommended drugs for treatment of gonococcal infections include the cephalosporins, ceftriaxone and cefixime, which are not inactivated by gonococcal penicillinase. 

An active dipeptide transport system that depends on hydrogen ions takes up non-ester amino-beta-lactams (penicillin, amoxicillin, and oral first-generation cephalosporins) (337-339) and specific cephalosporins that lack the alpha-amino group (cefixime, ceftibuten, cefdinir, cef-prozil) (340,341). Nifedipine increases amoxiciUin and cefixime absorption, probably by stimulating the dipeptide transport system, since the serum concentrations of passively absorbed drugs and intestinal blood flow did not change (342-344). 

Regardless of which antibiotic is selected, careful attention to predetermined outcome measures should be monitored closely in each patient to determine the success or failure of the therapeutic intervention. Oral antibiotics with broader antibacterial spectra (e.g., cefixime, amoxicillin-clavulanate, fluoroquinolones, or aza-lides) that possess more potent in vitro activity against sputum isolates generally are not needed as initial therapy because chnical response often appears independent of the pathogen s in vitro susceptibility for many patients. ... 

Includes ceftriaxone (IM) and cefixime (PO) used in single dose for gonorrhea, cefotaxime (active versus most bacteria causing meningitis), and ceftizoxime (B. fragilis). 

McAteer, J.A. Hiltke, M.F. SOber, B.M. Faulkner, R.D. Liquid-chromatographic determination of five orally active cephalosporins-cefixime, cefaclor, cefadroxil, cephalexin, and cephradine-in human serum. Clin.Chem., 1987, 33, 1788—1790... 

Aminothiazol methyloxime acetic acid 19 (ATMAA) is commercially available as is the proprietary activated form of ATMAA known as DAMA 20. ATMAA side chain and its close relations are critically important structural features of third- and fourth-generation commercially viable cephalosporin-based antibiotics related to cefovecin, such as cefetamet pivoxil, cefpodoxime proxetil, cefuroxime axetil, cefpirome, cefotiam hexetil, cefdinir, ceftbuten, ceftiofur, and cefixime (Scheme... 

There are comparatively few orally active third-generation agents. This group currently is represented by ceftibuten, cefixime, cefdinir, and cefpodoxime proxetil. 

---