Cefetamet pivoxil

Nakashima M, Kosuge K, Ishii I, Ohtsubo M. [Influence of multiple-dose administration of cefetamet pivoxil on blood and urinary concentrations of carnitine and effects of simultaneous administration of carnitine with cefetamet pivoxil.]Jpn J Antibiot 1996 49(10) 966-79. 

Holford NH, Ambros RJ, Stoeckel K. Models for describing absorption rate and estimating extent of bioavailability application to cefetamet pivoxil.Pharmacokinet Biopharm, 1992 20 421-442. 

Blouin RA, Kneer J, Ambros RJ, Stoeckel K. Influence of antacid and ranitidine on the pharmacokinetics of oral cefetamet pivoxil. Antimicrob Agents Chemother 1990 34(9) 1744-8. 

Aminothiazol methyloxime acetic acid 19 (ATMAA) is commercially available as is the proprietary activated form of ATMAA known as DAMA 20. ATMAA side chain and its close relations are critically important structural features of third- and fourth-generation commercially viable cephalosporin-based antibiotics related to cefovecin, such as cefetamet pivoxil, cefpodoxime proxetil, cefuroxime axetil, cefpirome, cefotiam hexetil, cefdinir, ceftbuten, ceftiofur, and cehxime (Scheme... 

No clinically significant interactions appear to occur between an aluminium/magnesium hydroxide antacid and cefaclor AF, ce-falexin, cefetamet pivoxil, cefixime or cefprozil between Alka-Seltzer and cefixime or between ceftibuten and Mylanta. In contrast, antacids reduce the bioavailability of cefpodoxime proxetil. 

Blouin RA, Kneer J, Stoeckel K. Pharmacokinetics of intravenous cefetamet (Ro 15-8074) and oral cefetamet pivoxil (RO-8075) in your and elderly subjects. Antimicrob Agents... 

Koup JR, Dubach UC, Brandt R, Wyss R, Stoeckel K. Fliarmacokinetics of cefetamet (Ro 15-8074) and cefetamet pivoxil (Ro 15-8075) after intravenous and oral doses in humans. Antimicrob Agents Chemoti er( 9ZZ) 32, 573-9. 

Tam YK, Kneer J, Dubach UC, Stoeckel K. Effects of timing of food and fluid volume on cefetamet pivoxil absorption in healthy normal volunteers. Antimicrob Agents Chemother (1990)34,1556-9. 

Ranitidine 150 mg twice daily for 4 days did not affect the pharmacokinetics of cefetamet pivoxil 1 g given to 18 healthy subjects after breakfast. ... 

As long as cefuroxime is taken with food (as is recommended ), any interaction is minimal. The bioavailability of cefetamet pivoxil, and cefpodoxime proxetil, are also enhanced by food so it is probable that interaction with dmgs which raise gastric pH may be similarly minimised. 

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