CD8+ T-lymphocytes

Ueno T, Fujiwara M, Tomiyama H, Onodera M, Takiguchi M (2004) Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes. Eur J Immunol 34 3379-3388... 

Walker CM, Levy JA (1989) A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 66 628-630 Walker RE, Bechtel CM, Natarajan V, Baseler M, Hege KM, Metcalf JA, Stevens R, Hazen A, Blaese RM, Chen CC, Lehman SF, Palensky J, Wittes J, Davey RT, Falloon J, Polls MA, Ko-vacs JA, Broad DF, Levine BL, Roberts MR, Masur H, Lane HC (2000) Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection. Blood 96 467 74... 

Zhu Y, Antony J et al (2006) CD8-t lymphocyte-mediated injury of dorsal root ganghon neurons during lentiviras infection CD 154-dependent ceU contact neurotoxicity. J Neurosci 26(13) 3396-3403 Zhu Y, Antony JM et al (2007) Didanosine causes sensory neuropathy in an HIV/AIDS animal model impaired mitochondrial and neurotrophic factor gene expression. Brain 130(Pt 8) 2011-2023... 

Inflammation is present in the lungs of all smokers. It is unclear why only 15% to 20% of smokers develop COPD, but susceptible individuals appear to have an exaggerated inflammatory response.5 O The inflammation of COPD differs from that seen in asthma, so the use of anti-inflammatory medications and the response to those medications are different. The inflammation of asthma is mainly mediated through eosinophils and mast cells. In COPD the primary inflammatory cells include neutrophils, macrophages, and CD8+ T lymphocytes. 

Gazinelli, R.T., Hakim, F.T., Hieny, S., Shearer, G.M. and Sher, A. (1991) Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-y production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. Journal of Immunology 146, 286-292. 

Mittrucker, H.W. et al., Role of CD28 for the generation and expansion of antigen-specific CD8+ T lymphocytes during infection with Listeria monocytogenes, J. Immunol., 167, 5620, 2001. 

HLA-presented Epstein-Barr virus peptides recognized by CD4(+) or CD8(+) T lymphocytes... 

LPS can be directly mitogenic for T cells [130], but the antitumoral activity of lymphocytes depends on antigen recognition by their TCR in the context of the major histocompatibility complex (MHC) class I or n. Though LPS enhance it, T lymphocyte activity requires APC [131]. The effect of LPS on T lymphocytes has been shown to depend on monocytes independent of MHC, but to be due to the secretion of costimulatory signals and IL-12 in humans [132]. In vivo, LPS induces principally the proliferation of CD8+ T lymphocytes, but also that of CD4+ T and B lymphocytes through the activation of APC and secretion of IFN 0(7(3 in C57BL/6 mice [133],... 

Geretti, A. M., van Els, C A C M, Poelen, M. C. M, and Osterhaus, A D. M. E (1993) Preservation of phenotype and function of positively selected virus-specific CD8+ T lymphocytes following anti-Fab detachment from immunomagnetic beads J Immunol Methods 161, 129-133... 

Alefacept (Amevive) is an immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 linked to the Fc portion of human IgGl. Alefacept interferes with lymphocyte activation, which plays a role in the pathophysiology of psoriasis, resulting in a reduction in subsets of CD2 T lymphocytes and circulating total CD4 and CD8 T lymphocyte counts. Alefacept is indicated for the treatment of... 

Christianson, S. W., Shultz, L. D. and Leiter, E. H. (1993) Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice relative contributions of CD4+ and CD8+ T lymphocytes from diabetic versus prediabetic NOD.NON-24/y 1 donors. Diabetes 42, 44-55. 

Lider, O., Santos., L. M., Lee, C. S., Higgins, P. J., and Weiner, H. L. 1989. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein, II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes. J. Immunol 142 748-752. 

Figure 9.4a and 9.46 provides a detailed analysis of the test article s effect on the CD4 and CD8 T lymphocyte populations, respectively. The CD4 counts showed a 47% reduction from baseline in the treatment group (circles, Figure 9.4a) and the CD8 counts showed a 53% reduction from baseline in the treatment group (circles, Figure 9.46). The placebo group (squares, Figure 9.4a and 9.46) showed a stable profile over time.

Hapten-specific CD8+ T lymphocytes, likely the major effector population, are directly cytotoxic to chemical exposed keratinocytes and also release cytokines that boost the inflammatory response. In addition, Thl cells release a number of cytokines and chemokines that promote inflammation and activate mast cells and, in the presence of IFNy, are also capable of killing keratinocytes. Although the hapten may persist in skin for some time, this reaction is self-limited. CD4+ regulatory T cells that secrete IL-10 (similar to those described in relation to UV-induced immune suppression in Section 32.4.3) appear to play an important role in this regulation. 

Anderson P, Nagler-Anderson C, O Brien C, Levine H, Watkms S, Slayter HS, Blue ML, Schlossman SF (1990) A monoclonal andbody reacdve widi a 15-kDa cytoplasmic granule-associated prolem defines a subpopuladon of CD8+ T lymphocytes. J Immunol 144 574—582. 

Hanoi E, Sdnchcombe JC, Saito M, AsquidiBE, Taylor GP, Tanaka Y, Weber JN, Giiffidis GM, Bangham CR (2000a) Eratricide among CD8(+) T lymphocytes naturally infected widi human T cell lymphotropic virus type I. Immunity 13 657—664. 

Sanchez-Ramon S, Bellon JM, Resino S, Canto-Nogues C, Gurbindo D, Ramos JT, Munoz-Femandez MA (2003) Low blood CD8 + T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children. Pediatrics 111 E168-175. 

Hertl M, Bohlen H, Jugert F, Boecker C, Knaup R, Merk HE. Predominance of epidermal CD8+ T lymphocytes in bullous cutaneous reactions caused by beta-lactam antibiotics. J Invest Dermatol 1993 101(6) 794-9. 

Podoba, J.E. and Stevenson, M.M. (1991). CD4( ) and CD8( ) T lymphocytes both contribute to acquired immunity to blood-stage Plasmodium chabaudi AS. Infect. Immun. 59, 51-58. 

Fig. 8.9 Schematic of the processing of a protein into peptide fragments for presentation by MHC. (a) The synthesized protein ( ) is present in the cytoplasm of the cell and is degraded into peptide by the proteasome. The derived peptide fragments are presented by MHC I to cytotoxic CD8+ T lymphocytes, (b) Protein ( ) is endocytosed by an APC (antigen-presenting cell) and processed into peptide within lysosomes. The derived peptide fragments are presented by MHC II to helper CD4+ T lymphocytes.

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