Cardiovascular tissue engineering

Keywords Bone Cardiovascular tissue engineering Electrospinning Microfibers Multiscale fibrous scaffolds Nanofibers Neural... 

Sell SA et al (2009) Electrospinning of collagen/biopolymers for regenerative medicine and cardiovascular tissue engineering. Adv Drug Deliv Rev 61(12) 1007-1019... 

Balguid A et al (2009) Tailoring fiber diameter in electrospun poly(epsilon-caprolactone) scaffolds for optimal cellular infiltration in cardiovascular tissue engineering. Tissue Eng A 15(2) 437-444... 

Polyesters have also been processed into tubular form for orthopedic and cardiovascular tissue engineering applications. Meinig and co-workers evaluated bone regeneration using tubular PLLA membranes in mid-diaphyseal defects in rabbit radii. The membrane prevented soft tissue formation in the defect area, and it allowed woven bone to fill the defect. Local inflammation or systemic intolerance was not observed, and the membranes remained intact for the entire 64-week study. 

E. Rabkin, F.J. Schoen, Cardiovascular tissue engineering, Cardio-vasc. Pathol. 11 (2002) 305-317. 

Moroni F, Mirabells T. Decellularized matrices for cardiovascular tissue engineering. Am J Stem Cells 2014 3(l) l-20. 

Vara DS, Salacinski HJ, Kannan RY, Bordenave L, Hamilton G, Seifalian AM. Cardiovascular tissue engineering state of the art. Pathol. Biol. (Paris) 53 599-612,2005. 

Jockenhoevel, S. and T.C. Flanagan. 2011. Cardiovascular tissue engineering based on fibrin-gel-scaffolds. INTECH Open Access Publisher. 

Ye, Q., et al. 2000. Fibrin gel as a three dimensional matrix In cardiovascular tissue engineering. European Journal of Cardio-Thoracic Surgery 17(5) 587-591. 

Jockenhoevel, S., Zund, G., Hoerstrup, S.P., Chalabi, K., Sachweh, J.S., Demircan, L., et al., 2001. Fibrin gel-advantages of a new scaffold in cardiovascular tissue engineering. European Association for Cardio-Thoracic Surgery 19 (4), 424—430. 

Prasad, C.K., Krishnan, L.K., 2008. Regulation of endothelial cell phenotype by biomimetic matrix coated on biomaterials for cardiovascular tissue engineering. Acta Biomaterialia 4 (1), 182-191. 

Bouten CVC, Bankers PYW, Driessen-Mol A, Pedron S, Brizard AMA, Baaijens FPT. Substrates for cardiovascular tissue engineering. Adv Drug DeUv Rev 2011 63 221 1. 

M. Generali, P.E. Dijkman, S.P. Hoerstmp, Bioresorbable scaffolds for cardiovascular tissue engineering - Eur. Med. J. (n.d.) http //emjreviews.com/therapeutic-area/ interventional-cardiology/bioresorbable-scaffolds-cardiovascular-tissue-engineering/. 

Cardiovascular tissue engineering using functional marine biomaterials... 

Bianchi, F., Vassalle, C., Simonetti, M., Vozzi, G., Domenici, C., Ahluwalia,A. (2006). Endothelial cell function on 2D and 3D microfabricated polymer scaffolds Applications in cardiovascular tissue engineering. JBiomater Sci., Polym 17, 37-51. 

An example of a pulsatile-flow bioreactor for vascular grafts is shown in Figure 44.3. This design, used in the Laboratory of Cardiovascular Tissue Engineering at the University of Oklahoma, resembles the shell and tube concept of some heat exchangers. Flow circuits are separated into shell-side and tube-side to monitor (and control) system pressure and flow rates independently. Control valves downstream... 

Rabkin E, Schoen FJ. Cardiovascular tissue engineering. Cardiovasc Pathol 2002 11 305-17. 

Keywords Medical device, bone-tissue engineering, cardiovascular-tissue engineering, specific drug administration... 

Cardiovascular tissue engineering aims to create functional tissue scaffolds that can re-establish the structure and function of injured sites of the cardiovascular system. A considerable amount of cardiovascular therapeutics, particularly for major and serious disorders, involves the use of devices. Some of these may be implanted by surgery, whereas others are inserted via minimally invasive procedures involving catheterization. Although different synthetic materials have been used for the development of cardiovascular devices, PUs have several advantages over the others. Besides their biocompatibility and their mechanical flexibility [100-103], PUs have very high flexural endurance compared to most elastomers, making them prime candidates for cardiovascular implants. 

In particular, polymers are resilient and easy to fabricate and can be combined with specific drugs. Among many polymers, polyfmethyl methacrylate) and polyurethanes are highlighted due to their biocompatibility and the possibility to be used in several medical devices. PMMA is usually employed in bone tissue engineering, while PU has applications mainly in cardiovascular tissue engineering. Both polymers can be designed for a specific application, and they have already been used in the development of prostheses with controlled drug release. 

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