Bioresorbable scaffold

Hanker JS, Terry BC, Ambrose WW, Lupton CR, inventors University of North Carolina, assignee. Plaster of paris as a bioresorbable scaffold in implants for bone... 

Altman GH, Horan RL, Weitzel P and Richmond JC. The use of long-term bioresorbable scaffolds for anterior cruciate ligament repair. 7 Am Acad Orthop Surg. 2008 16 177-187. 

Grinberg, O., Binderman, I., Bahar, H., Zilberaian, M., 2010. Highly porous bioresorbable scaffolds with controlled release of bioactive agents for tissue-regeneration applications. Acta Biomaterialia 6, 1278-1287. http //dx.doi.Org/10.1016/j.actbio.2009.10.047. 

Bioresorbable scaffolds for cell delivery the tissue engineering approach... 

Resorbability is a basic scaffold requirement for TE applications. Bioresorbable scaffolds do not need to be removed in a second smgical intervention, and their... 

Figure 19.2 Microparticles implanted in the infarcted myocardium of a rat myocardial infarction model. The bioresorbable scaffold interacts with the host tissue, modulating macrophage polarization through the recruitment of antiinflammatory M2 macrophages and favoring tissue recovery. PLGA MP, poly(lactic-co-glycolic acid)-microparticle.

M. Generali, P.E. Dijkman, S.P. Hoerstmp, Bioresorbable scaffolds for cardiovascular tissue engineering - Eur. Med. J. (n.d.) http //emjreviews.com/therapeutic-area/ interventional-cardiology/bioresorbable-scaffolds-cardiovascular-tissue-engineering/. 

D printing was developed at Massachusetts Institute of Technology to process bioresorbable scaffolds for tissue engineering applications [106,107]. The technology involves formation of a powdered layer, followed by printing of binder solution onto the powder bed to form a first layer. The bed is then lowered to redeposit powder and... 

D printing has also been used to produce medical implants and tissue engineering constructs involving biocompatible and bioresorbable scaffolds. Skowyra... 

E. Strandberg, J. Zeltinger, D.G. Schulz, and G.E. Kaluza, Late positive remodeling and late lumen gain contribute to vascular restoration by a non-drug eluting bioresorbable scaffold A four-year intravascular ultrasound study in normal porcine coronary arteries, Circ. Cardiovasc. Interv., 5 (1), 39-46,2012. 

There are several approaehes in Tissue engineering to develop a 3D scaffold. The three main approaches are to seed the chondrocytes onto inert substrates, onto acellular matrix graft or onto a bioresorbable scaffold. 

The concept of a bioresorbable scaffold is a scaffold that is able to degrade over a period, preferably once the cells are conformed to integrate into native tissue of interest. However, the scope of this paper only focuses on the preliminary stage, which is creating the scaffold, seeding it with bovine chondrocytes and evaluating the degradation rate and matrix formation. 

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