Cardiovascular hypertrophy

Kita, S., Y. Matsumura, S. Morimoto, et al. Antihypertensive effect of sesamin. 11. Protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy. Biol PharmBull 1995 18(9) 1283-1285. Kamal-Eldin, A., D. Pettersson, and L. A. Appelqvist. Sesamin (compound from sesame oil) increases tocopherol levels in rats fed ad libitum. Lipids 1995 30(6) 499-505. 

Angiotensin II receptor blockers Eprosartan (Teveten] Losartan (Cozaar] Valsartan (Diovan] Reduce angiotensin ll-induced peripheral vascular resistance and cardiovascular hypertrophy/remodeling by blocking angiotensin II receptors on the heart and vasculature... 

Inagami, T., and Senbonmatsu, T. 2001. Dual effects of angiotensin II type 2 receptor on cardiovascular hypertrophy. Trends Cardiovasc. Med. 11 324—328. 

Acylated pyridoxal derivatives, (IV), prepared by Haque (6) were effective in the treatment of cardiovascular hypertrophy, hypertension, and congestive heart failure. 

Key Words o -Adrenergic receptor blood pressure cardiac cardiovascular hypertrophy knockout. 

Kita, S. et al., Anthihypertensive effect of sesamin. II. Protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy, Biol. Pharmacol. Bull., 18, 1283, 1995. 

Y Matsumura, S Kita, S Morimoto, K Akimoto, M Euruya, N Oka, T Tanaka. Antihypertensive effect of sesamine. 1. Protection against deoxycorticosterone acetate-salt-induced hypertension and cardiovascular hypertrophy. Biol Pharm Bull 18 1016-1019, 1995. 

Losartan blocks the vascular constrictor effect of Ang II, the Ang Il-induced aldosterone synthesis and/or release, and the All-induced cardiovascular growth. In various models of experimental hypertension, losartan prevents or reverses the elevated blood pressure and the associated cardiovascular hypertrophy similar to angiotensin converting enzyme (ACE) inhibitors. Subsequently con-tolled clinical trials revealed that losartan is a new and valuable drug for treatment of hyper-... 

Komer, P. (1995) Cardiovascular Hypertrophy and Hypertension Causes and Consequences, Blood Press Suppl. 2, 6-16. 

The antihistamines are used cautiously in patients with bronchial asthma, cardiovascular disease, narrow-angle glaucoma, symptomatic prostatic hypertrophy, hypertension, impaired kidney function, peptic ulcer, urinary... 

Patients with diabetes and hypertension should initially be treated with either P-blockers, ACE inhibitors, ARBs, diuretics, or calcium channel blockers. There is a general consensus that therapy focused on RAAS inhibition by ACE inhibitors or ARBs may be optimal if the patient has additional cardiovascular risk factors such as left ventricular hypertrophy or chronic kidney disease.2,3,59,67... 

Cardiovascular Worsening hypertension, edema, dyslipi-demia, left ventricular hypertrophy, electrocardiographic changes and chronic heart failure. 

The progenitor cells of the kidney produce 90% of the hormone erythropoietin (EPO), which stimulates red blood cell (RBC) production. Reduction in nephron mass decreases renal production of EPO, which is the primary cause of anemia in patients with CKD. The development of anemia of CKD results in decreased oxygen delivery and utilization, leading to increased cardiac output and left ventricular hypertrophy (LVH), which increase the cardiovascular risk and mortality in patients with CKD. 

Cardiovascular Left ventricular hypertrophy, ECG changes, congestive heart failure Neurologic Impaired mental cognition Genitourinary Sexual dysfunction... 

Cardiovascular diseases hypertension, coronary heart disease, cardiomyopathy, left ventricular hypertrophy, and arrhythmia. 

Special risk patients Administer with caution to patients with thyroid disease, diabetes mellitus, cardiovascular disease, coronary artery disease, hypertension, peripheral vascular disease, heart disease, ischemic heart disease, increased intraocular pressure, or prostatic hypertrophy. 

Special risk patients Use antihistamines with caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, bladder neck obstruction, bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, and hypertension. 

D. Kava is often recommended for anxiety, and it appears significantly more effective than placebo for this condition. Garlic is used for cardiovascular benefits, saw palmetto for prostatic hypertrophy, and ginkgo as a cerebral vasodilator. Echinacea is considered an immunomodulating herb with potential benefit in viral illnesses. 

Usewith caution in older patients with Cardiovascular disease, prostatic hypertrophy or other conditions which increase the risk of urinary retention... 

Contraindications Bladder neck obstruction due to prostatic hypertrophy, cardiospasm, intestinal atony, myasthenia gravis in those not treated with neostigmine, narrow-angle glaucoma, obstructive disease of the GI tract, paralytic ileus, severe ulcerative colitis, tachycardia secondary to cardiac insufficiency or thyrotoxicosis, toxic megacolon, unstable cardiovascular status in acute hemorrhage... 

Increased production of ET-1 has been implicated in a variety of cardiovascular diseases, including hypertension, cardiac hypertrophy, heart failure, atherosclerosis, coronary artery disease, and myocardial infarction. ET-1 also participates in pulmonary diseases, including asthma and pulmonary hypertension, as well as in several renal diseases. 

There is evidence that by acting on B2 receptors, bradykinin may play a beneficial, protective role in cardiovascular disease. Selective B2 agonists are available and have been shown to be effective in some animal models of human cardiovascular disease. These drugs may have potential for the treatment of hypertension and myocardial hypertrophy. 

---