Carcinoid metastatic

Neoplasm Carcinoma Bronchial adenoma Bronchial carcinoid Metastatic disease Endometriosis... 

B. Indications and use Sandostatin is indicated to reduce blood levels of growth hormone and IGF-I (somatomedin-C) in acromegaly patients who have had inadequate response to or cannot be treated with surgical resection, pituitary irradiation, or bromocriptine mesylate at maximally tolerated doses. It is also indicated for the symptomatic treatment of patients with metastatic carcinoid tumors, where it suppresses or inhibits the severe diarrhea and flushing episodes associated with the disease, and for the treatment of the profuse watery diarrhea associated with VIP (vasoactive intestinal peptide)-secreting tumors (vipomas). 

Treatment of carcinoid and vasoactive intestinal peptide acromegaly (reduce blood levels of growth hormone), symptomatic treatment of metastatic carcinoid tumors, and profuse water diarrhea associated with intestinal tumors... 

Control of symptoms in patients with metastatic carcinoid (severe diarrhea and flushing episodes) and vasoactive intestinal peptide-secreting tumors (profuse water y diarrhea)... 

A 70-year-old patient with a metastatic carcinoid tumor of the liver presented with a hypertensive crisis after being given pethidine 10 mg/hour by continuous intravenous infusion (4). The patient remained hypertensive with a systolic blood pressure of 210 mmHg, even after chemoembolization of the tumor. The blood pressure... 

Octreotide, a synthetic octapeptide analog of endogenous somatostatin, is prescribed for the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide-secreting tumors (VIPomas). Metastatic intestinal carcinoid tumors secrete excessive... 

Brain tumors Carcinoid tumors Chronic lymphocytic leukemia Colorectal cancer Esophageal cancer Head and neck cancers Kaposi s sarcoma Metastatic melanoma Mycosis fungoides Non-small-cell lung cancer Ovarian cancer ... 

Stain Carcinoid Tumor Paraganglioma Medullary Melanoma Renal Cell Metastatic (Thyroid CA, Carcinoma, or Lung Carcinoma)... 

These three neuroendocrine tumors of the larynx all display positivity for typical neuroendocrine markers such as chromogranin, synaptophysin, and neuron-specific enolase. They may also be positive for carcinoembryonic antigen (CEA) or epithelial membrane antigen (EMA). Atypical carcinoid and SCNEC can also express other neuroendocrine markers such as serotonin, calcitonin, and somatostatin. TTE-1 is probably not a useful marker to distinguish metastatic pulmonary small cell carcinoma from primary tumors in the head and neck because up to 50% of extrapulmonary small cell carcinomas are positive for TTR-l.i 8... 

Mooney EE, Dodd LG, Otrry TD, et al. Middle ear carcinoid an indolent tumor with metastatic potential. Head Neck. 1999 21(l) 72-77. 

FIGURE 10.36 A, Metastatic carcinoid involving the liver. Immunoperoxidase stain for chromogranin A shows strong positivity in tumor cells. B, Metastatic carcinoid involving the liver. Immunoperoxidase stain for serotonin shows strong positivity in tumor cells. 

Carcinoid tumor, metastatic, lung 80 primary Sclerosing hemangioma of 100 lung—cuboidal cells and polygonal cells... 

This is one differential in which immunohistochemistry can be of utmost importance. Numerous cytologic and architectural similarities exist between HCC and metastatic well-differentiated neuroendocrine neoplasia (carcinoids and pancreatic endocrine neoplasia) They are both cellular, stroma-poor tumors that have a delicate sinusoidal vasculature and relatively monotonous cells with fair amount of cytoplasm and round nuclei. A panel of "neuroendocrine markers" (chromogranin, synapto-physin, and CD56) combined with "hepatocytic" markers (Hep Par-1 and polyclonal-CEA, and FISH for albumin) can be helpful. 

The overwhelming majority of neuroendocrine neoplasms occurring in the liver are metastatic. Well to moderately differentiated neuroendocrine neoplasms (e.g., carcinoids, pancreatic endocrine neoplasms, medullary thyroid carcinomas) may mimic primary hepatocellular processes, and thus immunohistochemistry with antibodies for chromogranin, synaptophysin, and CD56 can be extremely helpful, as discussed earlier. They may also be positive for MOC-31 but not for Hep Par-1. In contrast, HCC may occasionally show focal neuroendocrine differentiation and may stain for synaptophysin. 

Tash JA, Reuter V, Russo P. Metastatic carcinoid tumor of the prostate. J Urol. 2002 167 2526. 

FIGURE 18.46 Carcinoid tumors in the ovary can be found with other tissues as a component of a teratoma. They can aiso be primary in the ovary but not associated with other teratomatous tissues, in which case they are viewed as monodermai teratomas. Finaiiy, they can be metastatic from the appendix, smaii intestine, or other sites. Regardiess of their origin, they show cytopiasmic staining for chro-mogranin, as shown here, and for synaptophysin. 

Rabban JT, Lerwill ME, McCluggage WG, et al. Primary ovarian carcinoid tumors may express CDX-2 A potential pitfall in distinction from metastatic intestinal carcinoid tumors involving the ovary. Int J Gynecol Pathol. 2009 28 41-48. 

Carcinoid tumors—Symptomatic treatment of patients with metastatic carcinoid tumors, where... 

Approved uses for the drug include the control of diarrhea associated with vasoactive intestinal peptide tumors and metastatic carcinoid tumors. Other uses include the control of diarrhea associated with AIDS and with pituitary tumors. 

Gastric cancer compromises about 10% of all cancers world-wide [33]. The majority of the malignancies of the stomach are adenocarcinomas. Lymphomas, carcinoid tumors and sarcomas make up the remaining gastric neoplasms. The most efficacious curative therapy to date has been surgical resection. In experienced hands, surgical resection for palliation has mortality as low as 8% and nearly 25% may survive two years after the operation [34]. However, patients with metastatic disease... 

Items 1-2 Your patient has been diagnosed with a rare metastatic carcinoid tumor. This neoplasm is releasing serotonin, bradykinin, and several unknown peptides. 

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