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Carcinogens in liver cultures

Detection of Chemical Mutagens/Carcinogens in Liver Cultures... [Pg.63]

Williams, G.M. 1980. The detection of chemical mutagens/carcinogens by DNA repair and mutagenesis in liver cultures In Chemical Mutagens, Principles and Methods for Their Detection vol. 6, eds. F.J. deSerres, A. [Pg.87]

Marayama, H., Tanaka, T. Williams, GM. (1990) Effects of the peroxisome proliferator di(2-ethylhexyl)phthalate on enzymes in rat liver and on carcinogen-induced liver altered foci in comparison to the promoter phenobarbital Toxicol. Pathol., 18, 257-267 Matsushima, T, Muramatsu, M. Haresaku, M. (1985) Mutation tests on Salmonella typhimurium by the preincubation method. Prog. Mutat. Res., 5, 181-186 Matthews, E.J., DelBalzo, T. Rundell, J.O. (1985) Assays for morphological transformation and mutation to ouabain resistance of Balb/c-3T3 cells in culture. Prog. Mutat. Res., 5, 639-650... [Pg.138]

Hollaender, pp. 61-79. New York Plenum. Williams, G.M. 1980. Liver culture indicators for the detection of chemical carcinogens. In Short-Term Tests for Chemical... [Pg.87]

These two processes are considered to be the Initiating events In the carcinogenic action of aflatoxln Bj. Mutagenicity Is difficult to assess In liver or In primary cultures of hepatocytes because liver cells replicate very slowly. However, the extent of covalent binding of aflatoxln B to macromolecules, particularly to DNA, corelates well with species susceptibility to carcinogenesis. [Pg.148]

The first cell-mediated mutagenesis system developed by Huberman and Sachs uses fibroblasts to activate the carcinogen and mutable V79 cells which are incapable of activating most carcinogens. This approach has demonstrated a correlation between polycyclic hydrocarbons and mutagenic activity of in-vivo carcinogenic activity. However, cultured fibroblasts are not able to activate certain classes of compounds, including those which cause cancer of the liver. ... [Pg.267]

Williams, G.M. (1976a). Carcinogen-induced DNA repair in primary rat liver cell cultures a possible screen for chemical carcinogens. Cancer Lett. (Shannon, Ire.) 1 231-236. Williams, G.M. (1976b). The detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures. Cancer Res. 37 1845-1851. [Pg.689]

Williams GM. 1977. Detection of chemical carcinogens by unscheduled DMA synthesis in rat liver primary cell cultures. Cancer Res 37 1845-1851. [Pg.127]

In making its overall evaluation of the carcinogenicity to humans of di(2-ethyl-hexyl) phthalate, the Working Group took into consideration that (a) di(2-ethylhexyl) phthalate produces liver tumours in rats and mice by a non-DNA-reactive mechanism involving peroxisome proliferation h) peroxisome proliferation and hepatocellular proliferation have been demonstrated under the conditions of the carcinogenicity studies of di(2-ethylhexyl) phthalate in rats and mice and (c) peroxisome proliferation has not been documented in human hepatocyte cultures exposed to di(2-ethylhexyl) phthalate nor in the liver of exposed non-human primates. Therefore, the mechanism by which di(2-ethylhexyl) phthalate increases the incidence of hepatocellular tumours in rats and mice is not relevant to humans. [Pg.124]

See other pages where Carcinogens in liver cultures is mentioned: [Pg.66]    [Pg.14]    [Pg.61]    [Pg.133]    [Pg.853]    [Pg.126]    [Pg.470]    [Pg.186]    [Pg.1237]    [Pg.1953]    [Pg.27]    [Pg.136]    [Pg.250]    [Pg.120]    [Pg.412]    [Pg.836]    [Pg.52]    [Pg.148]    [Pg.124]    [Pg.397]    [Pg.64]    [Pg.181]    [Pg.407]    [Pg.443]    [Pg.32]    [Pg.192]    [Pg.10]    [Pg.309]   
See also in sourсe #XX -- [ Pg.61 , Pg.62 , Pg.63 , Pg.64 , Pg.65 , Pg.66 , Pg.67 , Pg.68 , Pg.69 , Pg.70 , Pg.71 , Pg.72 , Pg.73 , Pg.74 ]



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