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Carcinogenics epigenetic

DNA-damaging carcinogens Epigenetic carcinogens Progressor agents... [Pg.285]

In contrast to genotoxic carcinogens, epigenetic carcinogens act by a wide variety of mechanisms. Some of the possible epigenetic mechanisms of chemical carcinogenesis include peroxisome proliferation, inhibition of intercellular communication, microtubule alteration, hormonal imbalance, cytotoxicity, immunomodulation, inhibition of DNA methylation, etc. [Pg.184]

Epigenetic carcinogen A substance that causes cancer through a mechanism other than interaction with the genetic material. [Pg.1435]

Carcinogenic substances have conventionally been divided into two categories according to the presumed mode of action genotoxic and non-genotoxic (epigenetic). [Pg.164]

Costa M. 1995. Model for the epigenetic mechanism of action of nongenotoxic carcinogens. Am J Clin Nutr 61(suppl) 666S-669S. [Pg.228]

Lee Y-W, Klein CB, Kargacin B, et al. 1995. Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation A new model for epigenetic carcinogens. Molec Cell Biol 15 2547-2557. [Pg.241]

Epigenetic carcinogens. These are (i) tumor promoters mitogenic agents, causing proliferation of initiated cells. Examples are phorbol esters and peroxisome proliferators ... [Pg.273]

Epigenetic carcinogens cause the appearance of tumors without a genotoxic effect. This includes promotion, immunosuppression, cocarcinogenicity, and cytotoxicity. This group probably involves diverse mechanisms. They may act by... [Pg.280]

Epigenetic carcinogens cause tumors without a genotoxic effect and act via promotion, immunosuppression, cocarcinogenicity, and cytotoxicity. [Pg.285]

Epigenetic when used to describe a carcinogen, one that does not interact directly with genetic material. However, it may cause changes to DNA methylation, for example. [Pg.413]

Most substances classified as epigenetic carcinogens are promoters that act after initiation. Manifestations of promotion include increased numbers of tumor cells and decreased length of time for tumors to develop (shortened latency period). Promoters do not initiate cancer, are not electrophilic, and do not bind with DNA. The classic example of a promotor is a substance known chemically as decanoyl phorbol acetate or phorbol myristate acetate, a substance extracted from croton oil. [Pg.182]

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See also in sourсe #XX -- [ Pg.16 ]



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