Iball index

Early work on the structure of carcinogenic PAHs was done by John Iball at the University of Dundee, Scotland (29) he had suggested the use of the "Iball index" (30) as a measure of the... 

G. Klopman, K. Namboodiri, and A. N. Kalos, in Molecular Basis of Cancer, Part A Macromolecular Structure, Carcinogens and Oncogenes, R. Rein, Ed., Alan R. Liss, 1985, pp. 287—298. Computer Automated Evaluation and Prediction of the Iball Index of Carcinogenicity of Polycyclic Aromatic Hydrocarbons. 

This structure-activity relationship has been supported by several findings. According to Iball index which is proportional to the fraction of subject animal that shows a carcinogenic response divided by the mean latent period, dibezo(a,l)pyrene has the maximum value of 74, benzo(a)pyrene has 72, other compounds with a bay region in their structures have values above 50 while compounds such as fluoranthene, tiiphenylene, and phenanthrene without any bay or fjord region have a value of 0 [11]. 

The carcinogenicity of tar and other PAH containing materials was first demonstrated in animal experiments in the early 1900. Dibenzo[a,h]anthracene (DBA), synthesised in 1929, and benzo[a]pyrene (BaP), isolated from pitch in 1930, were the first pure PAH s shown to be carcinogenic to animals. The first review article on PAH carcinogenicity in mice was published in 1932 [40]. The Iball carcinogenicity index calculated from tumour incidence and latent period has been introduced in 1939 [4,41]. It is defined as ... 

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