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Bay-region theory

The Bay Region Theory of Polycyclic Aromatic Hydrocarbon Carcinogenesis... [Pg.69]

Yan, L.S. 1985. Study of the carcinogenic mechanism for polycyclic aromatic hydrocarbons — extended bay region theory and its quantitative model. Carcinogenesis 6 1-6. [Pg.1409]

Most of the more previous attempts to correlate carcinogenic potency with structural features of benzenoid hydrocarbons are related to the mechanism outlined above. The different quantitative models that have been developed can be distinguished with regard to the number of independent variables. One-variable theories (e.g. the so-called bay-region theory [94]) are normally inferior compared to two- [95] and three-variable theories which refer more explicitely to the different and partly competing metabolic reaction pathways. A particularely efficient model has been developed by v. Szentpaly [96]. In his so-called MCS model three important influences on carcinogenic potency are taken into account M, the initial epoxidation... [Pg.119]

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Bay region

The bay-region theory

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