Carcinogenicity central nervous system effects

Toxicology. Hexachloroethane is an eye irritant and causes kidney and central nervous system effects in animals. At high doses, it is carcinogenic to mice. 

Toxicology. 1,2,3-Trichloropropane is an irritant of the eyes and mucous membranes in experimental animals it has caused hepatic, renal, hematologic, and central nervous system effects it is carcinogenic to rodents exposed orally. 

CONSENSUS REPORTS lARC Cancer Review Group 3 IMEMDT 7,56,87 Animal Limited Evidence IMEMDT 39,369,86. OSHA PEL CL 0.1 ppm ACGIHTLV CL 0.1 ppm DFG MAK Animal Carcinogen, Suspected Human Carcinogen DOT CLASSIFICATION Forbidden SAFETY PROFILE Confirmed carcinogen with experimental carcinogenic data. Poison by inhalation. Central nervous system effects. Can be formed by thermal decomposition (>70°) from trichloroethylene. Symptoms include a disabling nausea and intense jaw pain. 

SAFETY PROFILE Moderately toxic by ingesdon. Quesdonable carcinogen with experimental tumorigenic data. Mutation data reported. Can cause chronic Uver damage and acute central nervous system effects. When heated to decomposition it emits highly toxic fumes of NOx. See also HYDRAZINE. 

SAFETY PROFILE Suspected carcinogen with experimental carcinogenic data. A human poison by inhalation. Human systemic effects by inhalation anorexia, nausea or vomiting. Corrosive to skin can produce severe burns. Human mutation data reported. A powerful fumigant gas that is one of the most toxic of the common organic halides. It is hemotoxic and narcotic with delayed action. The effects are cumulative and damaging to nervous system, kidneys, and lung. Central nervous system effects include blurred vision, mental confusion, numbness, tremors, and speech defects. 

CHRONIC HEALTH RISKS central nervous system effects blood disorders (increased methemoglobin decreased hemoglobin concentration) enlargement of spleen hemosiderosis of liver, kidneys and testes suspected carcinogen. 

CHRONIC HEALTH RISKS teratogenic and reproductive effects may alter genetic material central nervous system effects anorexia may have carcinogenic effects. 

Chronic exposure to relatively high concentrations of carbon disulfide may cause the central nervous system effects described above. In addition, chronic overexposure to carbon disulfide causes increased atherosclerosis, leading to risk of cardiovascular disease. Prolonged exposure of female workers to low concentrations of carbon disulfide has been associated with birth defects in offspring exposure limit values provide little margin of safety for risk of developmental effects. Carbon disulfide has not been found to be a carcinogen in humans. 

The acrylamide monomer may be neurotoxic, carcinogenic, genotoxic and hazardous to reproduction. Recent studies confirm that acrylamide exposures cause cancer and reproductive effects in animals, but epidemiological studies have not demonstrated these effects in humans. The neurotoxic effects from acrylamide exposure include peripheral nerve damage and central-nervous-system effects (Edvards 1975 Pye and Peachey 1976 Lambert et al. 1987 Dooms-Goossens et al. 1991). 

Vesicants are also systemic agents and readily pass through the skin to affect susceptible tissue including those that produce blood. For this reason they are often described as radio-mimetic poisons. In severe cases, systemic effects can include cardiovascular shock and multiorgan failure. Nitrogen vesicants can also cause central nervous system depression and cardiovascular shock. Both sulfur and nitrogen vesicants are carcinogenic. 

Toxieology. Chloroprene causes central nervous system abnormalities as well as skin and eye irritation. Reproductive, mutagenic, embryotoxic, and carcinogenic effects have been reported. 

As shown in Figure 2-4, there is a considerable body of data on the health effects of carbon tetrachloride in humans, especially following acute oral or inhalation exposures. Although many of the available reports lack quantitative information on exposure levels, the data are sufficient to derive approximate values for safe exposure levels. There is limited information on the effects of intermediate or chronic inhalation exposure in the workplace, but there are essentially no data on longer-term oral exposure of humans to carbon tetrachloride, most toxicity studies have focuses on the main systemic effects of obvious clinical significance (hepatotoxicity, renal toxicity, central nervous system depression). There are data on the effects of carbon tetrachloride on the immune system, but there are no reports that establish whether or not developmental, reproductive, genotoxic, or carcinogenic effects occur in humans exposed to carbon tetrachloride. 

Toluene, also known as methylbenzene, is the simplest member of the series known as alkylbenzenes, where an alkyl group, e.g. CH3, is directly attached to the benzene ring. As the use of benzene as a nonpolar solvent has long been prohibited because of its adverse effect on the central nervous system (CNS) and on bone marrow, as well as its carcinogenic property, toluene has replaced benzene as a nonpolar solvent. Although it has a CNS depressant property like benzene, it does not cause leukaemia or aplastic anaemia. 

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