Carcinogenic effects lung cancer

Carcinogenic effects Lung cancer, nasal cancer, sinus cancer... 

In order to establish a causal relationship rather than a pure association between the suspected carcinogen Rn-d and the induced effect lung cancer it is most important to know the individual Rn-d exposure. This is the particular weakness of all these studies since these measurements were not carried out fifteen to thirty years ago, this essential information cannot be provided by any of the available retrospective studies with a sufficient degree of reliability and accuracy (Steinhausler, in press). Therefore they have to rely on indirect estimation of past Rn-d exposure levels, using e.g. inference from uranium ore content. 

Fumimoto and Nakamura, 1971). Enriched in the soil, these metabolites can also be absorbed by the plants. In addition, the carcinogenic effect (lung and liver cancer) of arsenic compounds has recently been reported (Anonym, 1975). 

Although a number of epidemiological studies have reported an increased risk of lung cancer among occupationally exposed beryllium workers, deficiencies in the studies limit any unequivocal conclusion. Specific criticisms concern the lack of consideration of latent effects, of smoking history, and of exposure to other potential carcinogens and the underestimation of expected lung cancer deaths in comparison populations. "... 

BCME is also found as an impurity (1-7%) in the related CMME. Fourteen cases of lung cancer, mainly of oat cell type, were reported in a chemical plant where exposure to CMME occurred. In the reported epidemiological studies, insufficient evidence is available to separate the carcinogenic effects of the two compounds. ... 

Duimick JK, Elwell MR, Radovsky AE, et al. 1995. Comparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate chronic exposure in the lung. Cancer Research 55 5251-5256. 

The use of permanent hair dyes or the occupational exposure to these cosmetic products has recently been discussed because of a possible link to adverse long term effects like genetic effects or carcinogenic effects (l9 2, 3) Epidemiological studies seem to indicate an overrepresentation of lung and breast cancer among occupationally exposed people ( 3). Previously, 2,U-diaminotoluene (TDA), a very common product in hair dyes, has been proven to be an animal carcinogen after oral administration and subcutaneous injection k) ... 

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