Carcinogenesis Methylcholanthrene

Anderson LM, Jones AB, Riggs CW, Ohshima M (1985) Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene Positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism. Carcinogenesis, 6(9) 1389-1393. 

Mace prevented 3-methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of Swiss albino mice (Hussain and Rao, 1991). Oral administration of mace at a dose of lOmg/mouse/day for 7 days before and 90 days following carcinogen thread insertion reduced cervical carcinoma incidence by 50%. 

Hussain, S.P. and Rao, A.R. (1991) Chemopreventive action of mace (Myristica fragrans Houtt) on methylcholanthrene-induced carcinogenesis in the uterine cervix in mice. Cancer Letters 56(3), 231-234. 

De Jong M, Coppee MC, De Halleux F, Deckers C, Maisin H. Immunosuppression and carcinogenesis effects of azathioprine on induction of sarcomas by 3-methylcholanthrene. Neoplasma 1977 24 139-46. 

Riegel B, Watman WB, Hill WT. 1951. Delay of methylcholanthrene skin carcinogenesis in mice by... 

Dao TL, Sunderland H. 1959. Mammary carcinogenesis by 3-methylcholanthrene. I. Hormonal aspects in tumor induction and growth. J Natl Cancer Inst 23 567-585. 

Ozonation of benzo[r,s,t]pentaphene (7) followed by oxidative workup led to benzo[r,s,t]pentaphene-5,8-dione (12) (14%), phthalic acid (13) (4%), p-terphenyl-2,2, 3, 2"-tetra-carboxylic acid-2, 3 -anhydride (14) (10%), and 2-(o-car-boxyphenyl)- ,10-phenanthrenedicarboxylic acid anhydride (15) (3%), with a 56% recovery of unreacted 7, Ozonation of pentaphene (11) led to a peroxidic mixture which on oxidative workup led to 2,2 -binaphthyl-3,3 -dicarboxalde-hyde (16) (16%), 2,2 -binaphthyl-3,3 -dicarboxylic acid (17) (16%), and 13 (2%), with a 28% recovery of unreacted 11. A comparison of the reactivity to ozone of carcinogenic polycyclic aromatics benzo c]phenanthrene (1), 7,12-di-methylbenz [a] anthracene (2), 3-methylcholanthrene (3), dibenz[si,]] - (4), and dibenzlsi, ]anthracene (5), benzo Si -pyrene (6) and 7, and the noncarcinogen 11, all determined in our laboratory, leads us to conclude that there is no simple, consistent correlation between carcinogenicity, K-and L-region additivity towards ozone and the Pullmans electronic theory of carcinogenesis. 

Another interesting finding is the possible effect of l,25-(OH)2l>2 on the carcinogenesis process of skin. The compound is reported to suppress papilloma development in skin Induced by agents such as methylcholanthrene and promoters such as phorbol esters 13 however,... 

Suga, T., Shiio, T., Maeda, Y., and Chihara, G., Antitumor activity of Lentinen in murine syngenic and autochthonous hosts and its suppressive effect on 3-methylcholanthrene-induced carcinogenesis, Cancer Res., 44, 5132-5137,1984. 

Lubet RA, McCarvill JT, Putman DL et al. Effect of 3-aminobenzamide on the induction of toxicity and transformation by ethyl methanesulfonate and methylcholanthrene in BALB/3T3 cells. Carcinogenesis 1984 5(4) 459-462. 

The effects of cysteine pretreatment on hepatic microsomal demethylation of DMN and deethylation of diethylnitrosamine (DEN) were compared (34J). While cysteine inhibited DMN demethylase, no inhibitory effect on the production of acetaldehyde from DEN was observed. The hepatic deethylation of DEN was stimulated by pretreatment of rats with phenobarbitone, 3-methylcholanthrene, butylated hydroxy toluene, and DDT (318). The hepatic DEN deethylase activity in mice has been determined as a function of age and sex (389a). Peak activity was reached in both sexes between the seventh and fifteenth days of life thereafter, activity was higher in males. Mice treated with DEN at day 15 in carcinogenesis assays showed a higher incidence of liver tumors than those treated later, but no sex difference was observed in these experiments. 

Lentinan exerts prominent antitumor effects on various syngeneic and autochthonous tumors induced by 3-methylcholanthrene as well as on allogeneic tumors, as shown in Table 3 [5-8]. Carcinogenesis induced by 3-methylcholanthrene in SWM/Ms and DBA/2 mice is also suppressed by lentinan from 83% to 33%, and... 

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