Carcinogenesis Asbestos

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Asbestos exerts a synergistic influence on cigarette smoke (which contains several PAHs) in the development of bronchopulmonary cancers. This has important implications for workers occupationally exposed to asbestos, who also smoke. The interaction between cigarette smoke and asbestos may be explained partly by differences in the kinetics of PAH cell uptake when PAHs are preadsorbed on asbestos (Fournier and Pezerat 1986). Plutonium oxide (PuO2) has also been shown to enhance benzo[a]pyrene-induced lung carcinogenesis following simultaneous inhalation of both compounds (Metivier et al. 1984). 

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