Asbestos amosite

Evans, P.H., Brown, R.C. and Poole, A. (1983). Modification of the in vitro activities of amosite asbestos by surface derivati-zation. J. Toxicol. Environ. Health 11, 535-543. 

Ralston, J., and Kitchener, J. A. (1975). The surface chemistry of amosite asbestos, an amphibole silicate. J. Colloid Interface Sci. 50 242-249. 

The risk of gastrointestinal cancer from exposure to amosite asbestos has been suggested, but the reported studies are inconsistent (Peto et al., 1977 Selikoff et al., 1979 Morgan et al., 1985). Other cancers ascribed to asbestos exposure (ovarian, alimentary tract, for example) have low incidence (low SMRs), inconclusive evidence in establishing cause and effect. The amphibole materials, with their characteristic cleavage into sharp, finely divided particles and their low solubility (relative to chrysotile), are cited by many investigators as the bad actors in disease induction. 

Amosite asbestos I1" 2 1000 11 Yes Finer fiber bundles average... 

Figure 2. Free radical release, measured by means of ESR/spin trapping technique, from micronsized and nano-sized Fe203 particles compared with amosite (asbestos).27...

If asbestos is present and the sample is not a talc sample, it is most likely to be chrysotile since about 90% or more of the asbestos used in American industry is chrysotile. If the sample is taken from a shipyard, there is a high probability that it will be amosite asbestos. If asbestos is found in a talc sample, it is likely to be anthophyllite or tremolite-actinolite or an asbestos intermediate fiber chrysotile is a possibility, however. If the sample is insulation, expect a variety of fibers. 

SYNS AMOSITE ASBESTOS ASBESTOS (ACGIH) MYSORITE NCI-C60253A... 

Churg A, Stevens B. 1993. Absence of amosite asbestos in airway mucosa of non-smoking long term workers with occupational exposure to asbestos. Br J Ind Med 50(4) 355-359. 

Churg A, Sun J-P, Zay K. 1998. Cigarette smoke increases amosite asbestos fiber binding to the surface of tracheal epithelial cells. Am J Physiol 275(19) L502-L508. 

Churg A, Wright JL, Gilks B, et al. 1989b. Rapid short-term clearance of chrysotile compared with amosite asbestos in the guinea pig. Am Rev Respir Dis 139 885-890. 

Cook PM, Palekar LD, Coffin DL. 1982. Interpretation of the carcinogenicity of amosite asbestos and ferroactinolite on the basis of retained fiber dose and characteristics in vivo. Toxicol Lett 13 151-158. 

Davis JM, Addison J, Bolton RE, et al. 1986a. The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp Pathol 67 415-430. 

Dodson RE, Ford JO. 1991. Tissue reaction following a second exposure to amosite asbestos. Cytobios 68 53-62. 

Donaldson K, GolyasnyaN. 1995. Cytogenetic and pathogenic effects of long and short amosite asbestos. J Pathol 177 303-307. 

Donaldson K, Brown GM, Brown DM, et al. 1989. Inflammation generating potential of long and short fibre amosite asbestos samples. Br J Ind Med 46 271-276. 

Ehrlich R, Lilis R, Chan E, et al. 1992. Long term radiological effects of short term exposure to amosite asbestos among factory workers. Br J Ind Med 49 268-275. 

Gardner MJ, Powell CA, Gardner AW, et al. 1988. Continuing high lung cancer mortality among ex-amosite asbestos factory workers and a pilot study of individual anti-smoking advice. J Soc Occup Med 38 69-72. 

Hesterberg TW, Axten C, McConnell EE, et al. 1997. Chronic inhalation study of fiberglass and amosite asbestos in hamsters Twelve-month preliminary results. Environ Health Perspect Suppl 105 1223-1229. 

Hesterberg TW, Chase G, Axten C, et al. 1998a. Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation. Toxicol Appl Pharmacol 151 262-275. 

HSDB. 1999d. Amosite asbestos. Hazardous Substances Data Bank. National Library of Medicine, National Toxicology Information Program, Bethesda, MD. June 16, 1999. 

Kimizuka G, Azuma M, Ishibashi M, et al. 1993. Co-carcinogenic effect of chrysotile and amosite asbestos with benzo(a)pyrene in the lung of hamsters. Acta Pathol Jpn 43(4) 149-153. 

Kimizuka G, Shinozaki K, Hayashi Y. 1992. Comparison of the pulmonary responses to chrysotile and amosite asbestos administered intratracheally. I. Early phase of cellular reactions. Acta Pathol Jpn 42(10) 707-711. 

McCoimell EE, Rutter HA, Ulland BM, et al. 1983a. Chronic effects of dietary exposure to amosite asbestos and tremolite in F344 rats. Environ Health Perspect 53 27-44. 

NTP. 1983. National Toxicology Program. Technical report series no. 249. Lifetime carcinogenesis studies of amosite asbestos (CAS no. 121-72-73-5) in S Tian golden hamsters (feed studies). Research Triangle Park, NC U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health. NIH Publication No. 84-2505. 

Osgood C, Sterling D. 1991. Chrysotile and amosite asbestos induce germ-line aneuploidy in Drosophila. Mutat Res 261 9-13. 

Seidman H, Selikoff IJ, Gelb SK. 1986. Mortality experience of amosite asbestos factory workers Dose-response relationships 5 to 40 years after onset of short-term work exposure. Am J Ind Med 10 479-514. 

Selikoff IJ, Seidman H, Hammond EC. 1980. Mortality effects of cigarette smoking among amosite asbestos factory workers. J Natl Cancer Inst 65 507-513. 

Shepherd JR, Hillerdal G, McLarty J. 1997. Progression of pleural and parenchymal disease on chest radiographs of workers exposed to amosite asbestos. Occup Environ Med 54 410-415. 

Watanabe Y, Yamaguchi M, Kawakami Y, et al. 1993. Human CD4+ CD45RA+ T lymphocytes can be stimulated by crocidolite, anthophyllite and amosite asbestos in vitro. Int J Oncol 2(2) 209-212. 

Wright JL, Wiggs B, Churg A. 1991. Pulmonary h ertension indueed by amosite asbestos A physiologieal and morphologie study in the guinea pig. Lung 169 31-42. 

Regulatory agencies such as the U.S. Environmental Protection Agency (EPA) and Occupational Safety and Health Administration (OSHA) recognize six asbestos minerals chrysotile, a serpentine mineral and five amphibole minerals, actinolite asbestos, tremolite asbestos, anthophyllite asbestos, crocidolite asbestos, and amosite asbestos. Nonasbestiform amphibole minerals are not included in U.S. health regulations regarding asbestos because there is insufficient evidence that they will produce adverse health effects of the same type and severity produced by chronic exposure to asbestos. 

Churg A, Wright J, Wiggs B, et al. 1990. Mineralogic parameters related to amosite asbestos-induced fibrosis in humans. Am Rev Respir Dis 142 1331-1336. 

Graham A., Higinbotham J., Allan D., Donaldson K., and Beswick P. H. (1999) Chemical differences between long and short amosite asbestos differences in oxidation state and coordination sites of iron, detected by infrared spectroscopy. Occupat. Environ. Med. 56, 606-611. 

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