Carbohydrate digestion

The first member of this class, acarbose, was introduced in the early 1990s. a-Glucosidase inhibitors slow the intestinal process of carbohydrate digestion by competitive inhibition of the activity of a-glucosidase enzymes located in the brush border of the enterocytes... 

When a-glucosidase activity is inhibited, carbohydrate digestion is prolonged and takes place further along the intestinal tract. This in turn delays and spreads the period of glucose absorption, which reduces the extent of the postprandial rise in blood glucose concentrations. The effectiveness of a-glucosidase inhibitors is dq en-dent on the consumption of a meal rich in complex carbohydrate. 

KOIKE D, YAMADERA K, DiMAGNO E p (1995) Effect of a wheat amylase inhibitor on canine carbohydrate digestion, gastrointestinal function, and pancreatic growth. Gastroenterology. 108 1221-9. 

LiFSCHiTZ c H, GRUSAK M A, BUTTE N F (2002) Carbohydrate Digestion in Humans from a beta-Glucan-Enriched Barley Is Reduced. JNutr. 132 2593-6. 

Graham, H. (1991) The physical and chemical constitution of foods effects on carbohydrate digestion. In Euller, M.E. (ed.) In vitro Digestion for Pigs and Poultry. CAB International, Wallingford, UK, pp. 35-44. 

Acarbose and miglitol are a-glucosidase inhibitors of carbohydrate digestion in small intestine... 

Thus, it delays carbohydrate digestion, prolongs digestion time and reduces the rate of glucose absorption thereby lowering postprandial hyperglycemia. 

C. Final carbohydrate digestion by enzymes synthesized by the intestinal mucosal cells... 

The principal sites of dietary carbohydrate digestion are the mouth and intestinal lumen. Salivary a-amylase acts on dietary starch (glycogen, amylose, amylopectin), producing oligosaccharides. Pancreatic a-amylase continues the process of starch digestion. 

Effect of a Glucose-Lysine Reaction Mixture on Protein and Carbohydrate Digestion and Absorption... 

Hannan, J.M., Ali, L., Rokeya, B., Khaleque, J., Akhter, M., Flatt, P.R. and Abdel-Wahab, Y.H. (2007) Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. British Journal of Nutrition 97(3), 51 4-521. 

Know the names and modes of action of carbohydrate digestive enzymes found in the saliva and the small intestine, including the amylases and disaccharidases review how glucose and other hexoses are absorbed. 

The final products of carbohydrate digestion—glucose, fructose, and galactose—are absorbed by intestinal epithelial cells and enter the blood. 

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