Carbohydrate polyvalence

Carbohydrates Polyvalency Molecular recognition Lectins Cell adhesion Abbreviations... 

Houseman BT, Mrksich M (2002) Model Systems for Studying Polyvalent Carbohydrate Binding Interactions. 218 1-44 Hricovlniovd Z, see PetruS L (2001) 215 15-41... 

G. Thoma, M. B. Streiff, A. G. Katopodis, R. O. Duthaler, N. H. Voelcker, C. Ehrhardt, and C. Masson, Non-covalent polyvalent ligands by self-assembly of small glycodendrimers A novel concept for the inhibition of polyvalent carbohydrate-protein interactions in vitro and in vivo, Chem. Eur. J., 12 (2006) 99-117. 

Houk KN, Tantillo DJ, Stanton C, Hu Y (2004) What have Theory and Crystallography Revealed About the Mechanism of Catalysis by Orotidine Monophosphate Decarboxylase 238 1-22 Houseman BT, Mrksich M (2002) Model Systems for Studying Polyvalent Carbohydrate Binding Interactions. 218 1-44 Hricoviniovd Z, see Petrus L (2001) 215 15-41 Hu Y, see Houk KN (2004) 238 1-22... 

L. L. Kiessling and N. L. Pohl, Strength in numbers Non-natural polyvalent carbohydrate derivatives,... 

Model Systems for Studying Polyvalent Carbohydrate Binding Interactions... 

Kiessling LL, Pohl S. Strength in numbers non-natural polyvalent carbohydrate derivatives. Chem. Biol. 1996 3 71-77. Ragupathi G, Koide F, Livingston PO, Cho YS, Endo A, Wan Q, et al. Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer a synthetic route to anticancer vaccine candidates. J. Am. Chem. Soc. 2006 128 2715-2725. 

Boggs JM, Wang H. Co-clustering of galactosylceramide and membrane proteins in oligodendrocyte membranes on interaction with polyvalent carbohydrate and prevention by an intact cytoskeleton. J. Neurosci. Res. 2004 76 342-355. 

Most carbohydrates contain ethane-1,2-diol fragments, therefore they were also successfully included into crown ether macrocycles [313]. Polyvalency of carbohydrates was studied based on dendrimeric structures which were generated on successful glycosylations of highly branched polyethylene glycol units [314]. 

Synsorb. Because several of these supports are also used in solid-phase synthesis, an advantage of using carbohydrate-displaying beads as model systems for polyvalent recognition events is that libraries of saccharides can be assembled. Therefore, structure-function relationships can be determined rapidly. 

---