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Anticancer vaccine

Figure 4 Design of a chemically defined diepitope liposomal anticancer vaccine. Small unilamellar liposomes (PC/PG/Chol 75/20/50 molar ratio diameter 65nm) containing 5mol% of the synthetic thiol-reactive lipopeptide adjuvant anchor Pam3CSS-Mal were reacted, at 25°C and pH 6.5, with equimolar quantities of the peptides ErbB2 (p63-71), derivatized with a CG linker at its N-terminus, and HA307-319, derivatized with a C-linker at its C-terminus. Abbreviations PC, phosphatidylcholine PE, phosphatidylethanolamine SUV, small unilamellar vesicles. Source From Refs. 11, 74. Figure 4 Design of a chemically defined diepitope liposomal anticancer vaccine. Small unilamellar liposomes (PC/PG/Chol 75/20/50 molar ratio diameter 65nm) containing 5mol% of the synthetic thiol-reactive lipopeptide adjuvant anchor Pam3CSS-Mal were reacted, at 25°C and pH 6.5, with equimolar quantities of the peptides ErbB2 (p63-71), derivatized with a CG linker at its N-terminus, and HA307-319, derivatized with a C-linker at its C-terminus. Abbreviations PC, phosphatidylcholine PE, phosphatidylethanolamine SUV, small unilamellar vesicles. Source From Refs. 11, 74.
Allen JR, Harris CR, Danishefsky SJ. Pursuit of optimal carbohydrate-based anticancer vaccines preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBrl, and Lewisy antigens. J Am Chem Soc 2001 123 1890-1897. [Pg.354]

Williams LJ, Harris CR, Glunz PW, Danishefsky SJ. In pursuit of an anticancer vaccine a monomolecular construct containing multiple carbohydrate antigens. Tetrahedron Lett 2000 41 9505-9508. [Pg.357]

S. J. Danishefsky and J. R. Allen, From the laboratory to the clinic A retrospective on fully synthetic carbohydrate-based anticancer vaccines, Angew. Chem. Int. Ed., 39 (2000) 836-863. [Pg.390]

S. Grigalevicius, S. Chierici, O. Renaudet, R. Lo-Man, E. Deriaud, C. Leclerc, and P. Dumy, Chemoselective assembly and immunological evaluation of multiepitopic glycoconjugates bearing clustered Tn antigen as synthetic anticancer vaccines, Bioconjugate Chem., 16 (2005) 1149-1159. [Pg.390]

Possible anticancer vaccines have been synthesized from antibodies to cell-surface polysaccharides found on the surface of cancer cells. [Pg.690]

Kiessling LL, Pohl S. Strength in numbers non-natural polyvalent carbohydrate derivatives. Chem. Biol. 1996 3 71-77. Ragupathi G, Koide F, Livingston PO, Cho YS, Endo A, Wan Q, et al. Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer a synthetic route to anticancer vaccine candidates. J. Am. Chem. Soc. 2006 128 2715-2725. [Pg.600]

Synthesis and Evaluation of Anticancer Vaccine Candidates, C-Glycoside Analogs ofSTn and PSA... [Pg.4]

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