Carbohydrate drugs

As previously reported, fluoro-sugars play an important role in the development of potential biological targets such as enzyme inhibitors and carbohydrate drug candidates. 

In practice, the majority of TLC separations are qualitative or semiquantitative (visual comparison) in nature. However, modern computer-controlled densitometers are now available that scan sample and calibrator chromatograms in tracks on HPTLC plates and provide quantitative capabilities. Clinically relevant analytes that have been measured by TLC include amino acids, bile acids, carbohydrates, drugs, fipids, glycolipids, phospholipids, porphyrins, prostaglandins, steroid hormones, purines, pyrimidines, derivatives of nucleic acid, and urinary organic acids. The advantages of TLC include simphcity, rapidity, versatility, ability to process a large number of samples... 

Areas of special interest in carbohydrate drug research include the treatment of Helicobacter gastritis and prion-induced CNS disease. The following is organized in the approximate order as Sections 2.1 and 2.2, starting with diabetes research that continues to attract new carbohydrate-based agents. 

Carbohydrate-based therapeutics is now established, and the research and development pipeline for these agents is well outlined, all of which promises a robust future for carbohydrate drugs. 

LC is the most widely used of all of the analytical separation techniques. The reasons for the popularity of the method are its sensitivity, its ready adaptability to accurate quantitative determinations, its case of automation, its suitability for separating nonvolatile species or thermally fragile ones, and above all. its widespread applicability to substances that are important to industry, to many fields of science, and to the public. Examples of such materials include amino acids, proteins, nucleic acids, hydrocarbons, carbohydrates, drugs, terpenoids, pesticides, antibiotics, steroids, inetal-organic species, and a variety of inorganic substances,... 

Oh JK, Siegwart DJ, Matyjaszewski K (2007) Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs. Biomacromolecules 8 3326-3331... 

An Overview of Research Involving TLC Combined with ESI, DESI, ELSI, and Other Ionization MS Techniques for the Separation and Identification of Lipids, Carbohydrates, Drugs, and Natural Products... 

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