Carbohydrate-based drugs analysis

Other cavities mainly targeted as drug-delivery vehicles, have been exploited. Cucurbituril-based (CB) carbohydrate clusters (carbohydrate wheels) were synthesized by photoreaction of allyloxylated CB-6 with acetylthioglycosides. Twelve glucosyl, galactosyl and mannosyl residues (4 equivalents per reactive site, 2 days in MeOH) were introduced in 77, 76, and 83% yield, respectively, and finally deacetylated [71] (Fig. 17). The mannosylated CB cluster s affinity to ConA was examined by turbidimetric analysis. A 1,100-fold excess amount of methylman-noside had to be added to obtain a transparent solution as consequence of complete disruption of the cross-linking interaction. 

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