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Drug discovery complex carbohydrates

Automated solid phase synthesis, which has enabled synthesis libraries of peptides (15) and nucleic acids (16) and their use in drug discovery, is emerging as a useful tool for carbohydrate production (17). This technology has been difficult to develop largely due to the aforementioned inherent complexity of carbohydrates (18). Both nucleic acids and proteins can be assembled only in head-to-tail chains, whereas a chain of carbohydrates has the potential to elongate at any one of five different points on the sugar and these linkages can... [Pg.13]

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See also in sourсe #XX -- [ Pg.730 ]



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