Carbohydrate-based drugs

L. L. Kiessling, J. K. Pontrello, and M. C. Schuster, Synthetic multivalent carbohydrate ligands as effectors or inhibitors of biological processes, in C.-H. Wong, (Ed.), Carbohydrate-Based Drug Discovery, Wiley-VCH Weinheim, Germany, 2003, pp. 575-608. 

Since carbohydrates are ubiquitous in their interactions with the surroundings, it is very appealing to design carbohydrate-based drugs from a therapeutic... 

The next major class of drugs for peptic ulcer disease is the mucoprotectants and other protective agents. Sucralfate (4.158) is a carbohydrate-based drug (chapter 8) which forms an impenetrable paste that adheres to the stomach lining defect, providing a protective barrier. Misoprostol (4.159) is a semisynthetic prostaglandin derivative that promotes mucus production. Carbenoxolone (4.160) has a mineralocorticoid-type action that also promotes mucus production. 

S. -I. Nishimura Rational design and synthesis of carbohydrate-based drugs S. Perez The exquisite complexity of plant cell wall polysaccharides... 

Topiramate analogue 168 was enlisted into a comprehensive structural-activity relationship study [37], along with about a hundred varied synthetic analogues, which allowed identification of a new promising antiepileptic lead. From this study, carba-analogue 168 resulted three times more active than its corresponding carbohydrate-based drug. 

Wong CH (2003) Carbohydrate based drug discovery, Chap 24. Wiley-VCH, Weinheim... 

Seeberger PH, Werz DB. Automated synthesis of oligosaccharides as a basis for drug discovery. Nature Rev. Drug Disc. 2005 4 751-763. Wong C-H, ed. Carbohydrate-Based Drugs Discovery, vols 1-2. 2003. Wiley-VCH, Weinheim. 

Seeherger, P H, Solid-phase oligosaccharide synthesis. In Carbohydrate-Based Drug Discovery, Wong, C H, Ed., Wiley-VCH Verlag, Weinheim, Germany, pp. 103-127, 2003. 

Haslam SM, Khoo K-H, Dell A (2003) Sequencing of ohgosaccharides and glycoproteins. In Wong C-H (ed) Carbohydrate-based drug discovery, vol 2. Wiley VCH, Weinheim, p461... 

C.-H. Wong, Ed., Carbohydrate-based Drug Discovery, Wiley-VCH, Weinheim, 2003. 

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