Carbohydrate-based technology

Experimental work on a tumor-targeted, keto-carbohydrate-based technology is ad-... 

Despite the failures of carbohydrate companies, the venture community should continue to fund the carbohydrate-based technologies and drug discovery efforts because there will be a significant return on investment. Also needed to continue the pace of product introduction is the application of a multi-disciplinary approach to drug discovery. An important factor for the success of carbohydrate-based therapeutics in the last decade is the combination of glycobiology and carbohydrate chemistry. 

As we will soon discover, microarray-based technologies have found utility in a number of fields. While DNA arrays are the most technically mature and have the broadest application portfolio, we have witnessed the ever-increasing generation of new kinds of probe arrays antibody, antigen, enzyme, aptamer, carbohydrate, tissue, cell, and small molecule microarrays. The list undoubtedly will continue to expand. We can also describe microarrays in terms of prognostic, diagnostic, and predictive roles. A few examples that examine these applications are provided. 

Suven Life Sciences Synthon Chiragenics (Monmouth Junction, NJ, USA) Carbohydrate-based chiral technology N/A... 

My prediction is that if carbohydrate-like molecules become contenders as drug candidates, enzyme-based technology for their synthesis on an industrial scale may be the method of choice. 

This detailed article reports on the latest developments by three groups of researchers in the field of antibacterial surface treatments for glass, some polymers (such as PE, PP, nylon, and PETP), and porous materials which are carbohydrate-based. The three teams believe their antibacterial treatments will not worsen the increasing problem of bacterial resistance to antibiotics. Full details of the developments are provided. MASSACHUSETTS,INSTITUTE OF TECHNOLOGY NORTHEASTERN UNIVERSITY AMERICAN CHEMICAL SOCIETY NEW YORK,PACE UNIVERSITY NEW YORK,CITY UNIVERSITY LONG ISLAND,UNIVERSITY TOKYO,INSTITUTE OF TECHNOLOGY RENSSELAER POLYTECHNIC INSTITUTE PENNSYLVANIA,UNIVERSITY MASSACHUSETTS,UNIVERSITY ... 

For new carbohydrate-based therapeutics to continue at this pace of product registration in the intermediate and longterm, several objectives must be reached. Technologies supplying carbohydrates in quality as well as in quantity must be refined or discovered. This includes any combination of automated, solid and solution phase, and enzymatic synthesis. Wok to determine whether carbohydrate multivalency is a successful approach to new drug discovery, or at best, a way to make interesting research tools needs to be done. Likewise, examples that illustrate how carbohydrate-based libraries can actually accelerate drug discovery need to be shown. 

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