Cannabinoid effects

Lichtman AH, Wiley JL, LaVecchia KL, et al Acute and chronic cannabinoid effects characterization of precipitated withdrawal in dogs. Eur J Pharmacol 357 139-148, 1998... 

Marijuana and hashish are derivatives of the cannabis sativa plant 919 Cannabinoid effects in the CNS are mediated by the CB1 receptor 919 Endocannabinoids are endogenous ligands for the CB1 receptor 919 Endocannabinoids serve as retrograde messengers 920 There are many similarities between endogenous opioid and cannabinoid systems 921... 

Like all plants. Cannabis sativa L. forms a huge number of chemicals. Many of these have been identified.None of them, except the cannabinoids are specific for this plant and none of these non-cannabinoids has been found to contribute to the cannabinoid effects. Ffowever, very few have been directly tested together with cannabinoids for any biological effects. Recently, ElSohly and Slade, published a comprehensive review. Up to date, 70 natural cannabinoid compounds were documented. Althogether, they record 419 constituents nitrogenous compounds (27), amino acids... 

Misner DL, Sullivan JM (1999) Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons. J Neurosci 19 6795-6805 Moore SA, Nomikos GG, Dickason-Chesterfield AK, Schober DA, Schaus JM, Ying BP, Xu YC, Phebus L, Simmons RM, Li D, Iyengar S, Felder CC (2005) Identification of a high-affinity binding site involved in the transport of endocannabinoids. Proc Natl Acad Sci USA 102(49) 17852-7... 

Misner DL, Sullivan JM (1999) Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CAl neurons. J Neurosci 19 6795-6805... 

In slices of rat cerebellum, LTD of parallel fibre inputs to Purkinje cells can be induced by pairing low-frequency stimulation (1 Hz for 5 min) with post-synaptic depolarisation. Both WIN55, 212-2 (1 pM) and CP55,940 (400 nM) reduced the EPSC by about 50%, and impaired the induction of LTD, an effect which was blocked by rimonabant (1 pM) (Levenes et al. 1998). In this pathway, therefore, it appears that cannabinoid effects on synaptic plasticity may be secondary to changes in baseline responses. 

Sanudo-Pena MC, Patrick SL, Khen S, Patrick RL, Tsou K, Walker JM (1998) Cannabinoid effects in basal ganglia in a rat model of Parkinson s disease. Neurosci Lett 248 171— 174... 

Signalling pathway Cannabinoid effect Effect on cell number... 

We have initiated a series of studies to analyze CBjR gene structure, regulation, and expression in the mouse and human models to determine genotypic and haplotypic associations of CB,R gene with addictions and other neuropsychiatric disturbances. Genotypes at markers near the mouse Chr 4, 13.9 cM CB,/CNR locus in 9 mouse strains reveal apparent haplotypes that extend from at least D4Mit213 to D4Mit90. These haplotypes can be correlated with strain differences in cannabinoid effects. 

CBj This is derived mainly from the CB j mutant mice in which some cannabinoid effects are activated by W1N55212-2 or anandamide but not THC, CP55940, or HU210. This putative CB3r, which is a non-CBj, non-CBj, nonvanilloid receptor and is insensitive to rimonabant, may be specifically localized in some brain region to mediate specific physiological function. 

Cabral, G.A. (2002) Marijuana and cannabinoid effects in immunity and AIDS, in Biology of Marijuana, E.S. Onaivi, Ed., London Taylor and Francis, pp. 282-307. 

Arevalo C, de Miguel R, Hernandez-Tristan R. Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters. Pharmacol. Biochem. Behav. 70, 123-131 (2001). 

Arevalo, C., de Miguel, R. and Hernandez-Tristan, R. (2001) Cannabinoid effects on anxiety-related behaviors and hypothalamic neurotransmitters, Pharmacol Biochem Behav, 70 123-31. 

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