Cannabinoid CB2 receptor

Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urban P, Mackie K, Stella N, Makriyannis A, PiomeUi D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA, Identification and functional characterization of brainstem cannabinoid CB2 receptors, Science 310 329—332, 2005. 

Fernandez-Ruiz J, Romero J, Velasco G, Tolon RM, Ramos JA, Guzman M, Cannabinoid CB2 receptor A new target for controlling neural cell survival Trends Pharmacol Sci 28 39 5, 2007. 

Iwamura, H., Suzuki, H., Ueda, Y., Kaya, T., Inaba T. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor, J. Pharmacol. Exp. Ther. 2001, 296, 420-425. 

Oka, S., Yanagimoto, S., Ikeda, S., Gokoh, M., Kishimoto, S., Waku, K., Ishima, Y., and Sugiura, T. (2005). Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. J. Biol. Chem. 280, 18488—18497. 

Cannabinoid CB2 receptors Immunohistochemical localization in rat brain. Brain Res 1071 10-23. 

Onaivi ES, Ishiguro H, Gong JP, Patel S, Perchuk A, et al. 2006. Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann NY Acad Sci 1074 514-536. 

Lee SF, Newton C, Widen R, Friedman H, Klein TW (2001) Differ-endal expression of cannabinoid CB2 receptor mRNA in mouse immune cells subpopuladons and following B cell sdmuladon. Eur J PharTnacol 423 235—241. 

Sugiura, T., Kondo, S., Kishimoto, S., Miyashita, T., Nakan, S., Kodaka, T., et al. (2000). Evidence that 2-arachidonoylglycerol but no N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. Journal of Biological Chemistry, 275, 605-612. 

New DC, Wong YH (2003) BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor signalling via cAMP and inositol phosphates. FEBS Lett 536 157-160... 

Benito C, Nunez E, Tolon RM, Carrier EJ, Rabano A, Hillard CJ, Romero J (2003) Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer s disease brains. J Neurosci 23 11136-11141... 

Griffin G, Wray E, Tao Q, McAllister S, Rorrer W, Aung M, Martin B, Abood M (1999) Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528 further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. Eur J Pharmacol 377 117-125... 

On peripheral terminals, the activation of CBi and CB2 cannabinoid receptors was shown to inhibit nociceptive transmission, and both receptors seem to be implicated in mediating the existing endogenous cannabinoid tone (Calignano et al. 1998 Strangman et al. 1998 Hanus et al. 1999 Ko and Woods 1999). Thus, behavioural studies support a role for peripheral cannabinoid CB2 receptors in animal models of persistent pain and the existence of a synergism between CBi-and CB2 -mediated responses at this level (Malan et al. 2002). However, other studies do not support such a role of peripheral cannabinoid receptors (Di Marzo et al. 

CB2 receptor activation can also inhibit oedema and plasma extravasations produced by inflammation at a peripheral level (Malan et al. 2002). Cannabinoid CB2 receptors are likely located on non-neuronal cells in inflamed tissues, where they inhibit the release of inflammatory mediators that excite nociceptors (Mazzari et al. 1996). 

Xie XQ, Chen JZ, Billings EM (2003) 3D structural model of the G-protein-coupled cannabinoid CB2 receptor. Proteins 53 307-319... 

Hohmann AG, Farthing JN, Zvonok AM, Makriyannis A (2004) Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin. J Pharmacol Exp Ther 308 446-453... 

Nunez E, Benito C, Pazos MR, Barbachano A, Fajardo O, Gonzalez S, Tolon R, Romero J (2004) Cannabinoid CB2 receptors are expressed by perivascular microghal ceUs in the human brain an immunohistochemical study. Synapse 53 208-213... 

Nackley AG, Makriyannis A, Hohmann AG (2003a) Selective activation of cannabinoid CB2 receptors suppresses spinal Fos protein expression and pain behavior in a rat model of inflammation. Neuroscience 119 747-757... 

Nackley AG, Zvonok A, Makriyannis A, Hohmann AG (2004) Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. J Neurophysiol 92 3562-3574... 

Patel HJ, Birrell MA, Crispino N, Hele DJ, Venkatesan P, Barnes PJ, Yacoub MH, Belvisi MG (2003) Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. Br J Pharmacol 140 261 -268... 

Di Filippo C, Rossi F, Rossi S, DAmico M (2004) Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury involvement of cytokine/chemokines and PMN. J Leukoc Biol 75 453-459... 

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