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Cancer treatment angiogenesis inhibitor

Identification of the active component of Neovastat may elucidate its specific mode of acfion and potentially limit the side effects identified at the present time. This is particularly pertinent if, as expected, life-long administration is required, because the effects of chronic exposure and interactions between Neovastat and other therapies are not yet known. The positive safety profile and fhe oral administration route of Neovastat, however, are advantages in comparison with current therapies and some angiogenesis inhibitors. Thus, should antiangiogenic therapy become a mainstream therapy, Neovastat could play a substantial role in the treatment of cancer. [Pg.355]

In patients with blocked coronary blood vessels, coronary artery bypass grafting or angioplasty may be required. A potential new therapy involves agents that promote the formation of new blood vessels (angiogenesis). However, drugs that interfere with the formation of new blood vessels (angiogenesis inhibitors) may have a promising future in the treatment of cancer since they can cut off blood supply to tumors. [Pg.450]

The protein kinase C (PKC) family of serine/theronine kinases consists of at least 11 isoforms that are involved in cell proliferation, cell differentiation, gene transcription, tumorigenesis, and angiogenesis. PKC overexpression has been linked to several types of cancer such as breast, colon, renal cell, hepatocellular, non-small cell lung and prostate cancer. Therefore, PKC inhibitors may have potential for the treatment of various cancers. [Pg.19]

Nazer B, Humphreys BD, Moslehi J (2011) Effects of novel angiogenesis inhibitors for the treatment of cancer on the cardiovascular system focus on hypertension. Circulation 124 1687-1691... [Pg.429]

Ripin et al. [16] from Pfizer developed a highly efficient Heck reaction of iodide 31 and bis-Boc allylimide 32 in their synthetic scheme for 33, a selective ErbB2 angiogenesis inhibitor for the treatment of cancer. A Heck reaction beAveen 31 and 32 in the presence of 1 mol% Pd2(dba)j, followed by treatment of the resulting product with HCl gave 90 of 33 as a salt (Scheme 9.8). [Pg.337]

HDACs are a family of enzymes that catalyze the deacetylation of lysine side chain in chromatin. These enzymes are involved in a wide range of biological processes such as cell differentiation, proliferation, angiogenesis, and apoptosis. HDAC inhibitors have been clinically validated as a therapeutic strategy for cancer treatment. This topic has been covered by critical reviews [55-58]. The classic pharmacophore for HDAC inhibitors consists of three distinct structural motifs the zinc-binding group, a hydrophobic linker, and a recognition cap moiety. [Pg.36]


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See also in sourсe #XX -- [ Pg.87 , Pg.88 , Pg.89 , Pg.90 , Pg.91 , Pg.92 , Pg.93 , Pg.94 , Pg.95 , Pg.96 ]




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