Antiangiogenic therapy

Identification of the active component of Neovastat may elucidate its specific mode of acfion and potentially limit the side effects identified at the present time. This is particularly pertinent if, as expected, life-long administration is required, because the effects of chronic exposure and interactions between Neovastat and other therapies are not yet known. The positive safety profile and fhe oral administration route of Neovastat, however, are advantages in comparison with current therapies and some angiogenesis inhibitors. Thus, should antiangiogenic therapy become a mainstream therapy, Neovastat could play a substantial role in the treatment of cancer. 

Ebos JM, Kerbel RS (2011) Antiangiogenic therapy impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol 8 210-221... 

Boehm T, Folkman J, Browder T, et al. Antiangiogenic therapy of experimental cancer does not induce acquired resistance. Nature 1997 390 404-407. 

Shaheen RM, Davis DW, Liu W, et al. Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res 1999 59(21) 5412-5416. 

Herbst RS, Takeuchi H, Teicher BA. Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models. Cancer Chem Pharm 1998,41 497-504. 

F. Biankenberg, W.C. Eckelman, H.W. Strauss, M.J. Welch, A. Alavi, C. Anderson, S. Bacharach, R.G. Blasberg, M.M. Graham, W. Weber, Role of radionuclide imaging in triais of antiangiogenic therapy. [Review], Acad. Radiol. 7 (2000) 851-867. 

Lakka SS, Rao JS (2008) Antiangiogenic therapy in brain tumors. Expert Rev Neurother 8 1457-1473... 

Rege, T.A., Fears, C.Y. and Gladson, C.L. (2005) Endogenous inhibitors of angiogenesis in malignant gliomas nature s antiangiogenic therapy. Neuro-oncol. 7, 106—121. 

Rajkumar SV, Witzig TE. A review of angiogenesis and antiangiogenic therapy with thalidomide in multiple myeloma. Cancer Treat Rev 2000 26(5) 351-62. 

Guyer DR, Adamis AP, Gragoudas ES, Folkman J, Slakter JS, Yannuzzi LA. Systemic antiangiogenic therapy for choroidal neovascularization. What is the role of interferon alfa Arch Ophthalmol 1992 U0(10) 1383 1384. 

Combining photodynamic therapy with antiangiogenic therapy... 

There are a growing number of studies evaluating the combination of antiangiogenic therapy with cytotoxic procedures such as chemotherapy and radiation therapy... 

Combining photodynamic therapy with antiangiogenic therapy Charles J. Gomer, Angela Ferrario, Karl von Tiehl,... 

Kaban LB, Mulliken JB, Ezekowitz RA, Ebb D, Smith PS, Folkman J. Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferona-2a. Pediatrics 1999 103 1145-1149. 

Marler JJ, Rubin JB, Trede NS, Connors S, Grier H, Upton J, Mulliken JB, Folkman J. Successful antiangiogenic therapy of giant cell angioblastoma with interferon alfa 2b report of 2 cases. Pediatrics 2002 109 1-5. 

Abdollahi A, Hlatky L, Huber PE. Endostatin the logic of antiangiogenic therapy. Drug... 

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