Isoprenylcysteine carboxyl methyltransferase

Romano, J.D., and Michaelis, S. (2001). Topological and mutational analysis of Saccharomyces cerevisiae Stel4p, founding member of the isoprenylcysteine carboxyl methyltransferase family. Mol Biol Cell 12 1957-1971. 

Griggs, A.M., Hahne, K., and Hrycyna, C.A. (2010). Functional oligomerization of the Saccharomyces cerevisiae isoprenylcysteine carboxyl methyltransferase, Stel4p. J Biol Chem 285 13380-13387. 

Wright, L.P., Court, H., Mor, A., Ahearn, I.M., Casey, P.J., and Philips, M.R. (2009). Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. Mol Cell Biol 29 1826-1833. 

Bergo, M.O., Leung, G.K., Ambroziak, P., Otto, J.C., Casey, P.J., and Young, S.G. (2000). Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells. J Biol Chem 275 17605-17610. 

Ahmad, M., Zhang, Y., Papharalambus, C., and Alexander, R.W. (2002). Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells. Arterioscler Thromb Vase Biol 22 759-764. 

Lu, Q., et al. (2004). Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeabihty involvement of Rho A carboxyl methylation. Circ Res 94 306-315. 

Kramer, K., et al. (2003). Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. Mol Biol Cell 14 848-857. 

Bergo, M.O., et at (2001). Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J Biol Chem 276 5841-5845. 

Winter-Vann, A.M., et al. (2005). A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci USA 102 4336-4341. 

Baron, R.A., Peterson, Y.K., Otto, J.C., Rudolph, J., and Casey, P.J. (2007). Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules. Biochemistry 46 554-560. 

Donelson, J.L., Hodges, H.B., MacDougall, D.D., Henriksen, B.S., Hrycyna, C.A., and Gibbs, R.A. (2006). Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett 16 4420 423. 

Buchanan, M.S., et al (2007). Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Bioorg Med Chem Lett 17 3. 

Buchanan, M.S., et al (2008). Aplysamine 6, an alkaloidal inhibitor of Isoprenylcysteine carboxyl methyltransferase from the sponge Pseudoceratina sp. J Nat Prod 71 7. 

Garcia, J., Pereira, R., and de Lera, A.R. (2009). Total synthesis of the natural isoprenylcysteine carboxyl methyltransferase inhibitor spermatinamine. Tetrahedron Lett 50 5028-5030. 

Bergman, J.A., et al (2011). S-farnesyl-thiopropionic acid (FTP) triazoles as novel, potent inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt) manuscript submitted. ACS Med Chem Lett, (unpublished data). 

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