Cancer plasma membranes

Chen, Y. Pant, A. C. Simon, S. M., P-glycoprotein does not reduce substrate concentration from the extracellular leaflet of the plasma membrane in living cells, Cancer Res. 61, 7763-7768 (2001). 

Mackey, J. R., et al. Gemcitabine transport in Xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J. Natl. Cancer Inst. 1999, 91, 1876-1881. 

Multidrug resistance (MDR) is the name ascribed to the phenomenon whereby cancer cells and tumors develop resistance to chemotherapeutic agents. Conceptually, this can be viewed as a survival response whereby cancer cells endeavor to ward off cytotoxic compounds. Mechanistically, MDR is typically mediated by overexpression of P-glycoprotein (P-gp aka ABCB1) or other plasma membrane ATPases that export cytotoxic drugs used in chemotherapy, thereby reducing their efficacy. 

Bums, C. P., Luttenegger, D. G., Dudley, D. T., Buettner, G. R., and Spector, A. A., 1979, Effect of modification of plasma membrane fatty add composition on fluidity and methotrexate transport in L1210 murine leukemia cells. Cancer Res. 39 1726-1732. 

Ogbonme SM, Snhrbier A, Jones B, Cozzi SJ, Boyle GM, Morris M, McAlpine J, Johns TM, Scott KP, Sntherland JM, Gardner TTT, Le A, Lenarczyk D, Aylward JH, Parsons PG. (2004) Antitumor activity of 3-ingenyl angelate Plasma membrane and mitochondrial disruption and necrotic cell death. Cancer Res 64 2833-2839. 

Integral plasma membrane proteins from a human lung cancer cell line (62 prenylated proteins and 45 Ras family proteins) urinary proteins AGP-derived glycoproteins major and minor populated isoforms of antithrombin regulatory lipids in breath condensate ... 

Cellular membranes serve as (tie interface between the cell and the organism of which il is a part. It has been established that ihe movement of cells, as directed during growth and development, must involve, in some way. the plasma membranes. Il also has been observed that plasma membranes play some role in cancerous growth, where cell multiplication and migration proceed at an uncontrolled rate. Membranes are composed of lipids that interact with each uther in a watery medium to form a closed... 

A feature of most cancer cells is that they exhibit a disturbance of the ordered structures and biological regulation observed in normal cells. Evidence is presented, based on studies of living cells and on electron microscopy, which indicates that the arrangement of molecules within the plasma membrane and of subsurface microfilaments has certain properties that are similar to those of liquid crystals. These liquid crystalline properties are disturbed in malignant cells. 

Lee, W.J., Roberts-Thomson, S.J., Monteith, G.R., 2005a, Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. Biochem Biophys Res Commun 337, 779-783. 

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