Cancer hematopoietic neoplasms

Statistically non-significant SMRs were obtained for mortalities from the following hematologic-related cancers combined neoplasms of the lymphatic and hematopoietic tissues, lymphosarcoma and reticulosarcoma, Hodgkins disease, leukemia and aleukemia, other lymphatic neoplasms. 

Howard EB, Clarke WJ. 1970. Induction of hematopoietic neoplasms in miniature swine by chronic feeding of strontium-90. J Natl Cancer Inst 44(1) 21-38. 

Vinyl chloride has been associated with cancer in humans in a number of epidemiological studies. In four facilities engaged in the polymerization of vinyl chloride for at least 15 years, workers exposed for at least 5 years had a significant number of excess deaths due to malignant neoplasms (35 deaths observed, 23.5 expected). The excesses were found for four organ systems CNS (3 observed, 0.9 expected), respiratory system (12 observed, 7.7 expected) hepatic system (7 observed, 0.6 expected), and lymphatic and hematopoietic systems (4 observed, 2.5 expected). 

Secondary paraproteinemias may be seen in association with hematopoietic cancers (e.g., lymphomas and leukemias), other neoplasms (e.g., colon carcinoma), long-standing chronic urinary or biliary tract infection, rheumatoid factor related to IgM monoclonal protein, and amyloidosis. 

There is also no clear association between PCBs and hematopoietic or lymphatic cancers. Investigations of a cohort of Italian capacitor workers found statistically significantly increased mortality from hematological neoplasms in females in the first study (SMR=377, Cl 115-877, p<0.05) (Bertazzi et al. 

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