Cancer chemotherapy biologic response modifiers

J.S. Lazo. Bleomycin. In Cancer Chemotherapy and Biological Response Modifiers Vol 18, H.M. Pinedo, D.L. Longo, B.A. Chabner (Eds). Elsevier New York,... 

Jurcic JG, Scheinberg DA, Houghton AN, In Cancer Chemotherapy and Biological Response Modifiers Annual 16 (Eds Pinedo HM, Longo DL, Chabner BA), pp. 168-188. Elsevier Science, Amsterdam, 1996. 

IL-2 has been approved for the heatment of renal cell carcinoma and also has shown good activity in malignant melanoma. Both of these tumors are refractory to chemotherapy. IL-2 has also been used invesdgationally, both alone and in combinadon with LAK cells, with chemotherapy and with other biological response modifier s (BRM s) to d eat a variety of different cancers (e.g., head and neck carcinoma, colorectal cancer, cend al nervous system cancer etc). In addidon to cancer therapy, IL-2 has been used to d eat padents infected with human immunodeficiency virus and it has been used ex vivo to generate antiviral T cells which were reinfused into padents (Lewko and Oldham, 2003 Dorr, 1993). 

Hande KR. Topoisomerase II inhibitors. In Giaccone G, Schilsky R, Sondel P, editors. Cancer Chemotherapy and Biological Response Modifiers. Amsterdam Elsevier, 2003 103-25. 

Biological response modifiers are drugs that enhance the patients natural response to cancer. They are used only in specific types of cancer, usually if more conventional chemotherapy has failed. 

Interleukin-12 (IL-12) is one of a group of the related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-12 (IL-12) is made mainly by B lymphocytes and macrophages. Interleukin-12 (IL-12) causes other immune cells to make cytokines and increases the growth of T lymphocytes. Interleukin-12 (IL-12) may also block the growth of new blood vessels. A synthetic interleukin-12 (IL-12) is used as a biological response modifier to boost the immune system in cancer chemotherapy. Interleukin-12 (IL-12) is a type of cytokine of the factor which regulates the cell proliferation differentiation. 

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