Cancer cell lines, anticancer activity

Pihie AHL, Stanslas J, Din LB. Non-steroid receptor-mediated anti-proliferative activity of styrylpyrone derivative in human breast cancer cell lines. Anticancer Res 1998 18 1739-1743. 

Kawase, M. Sakagami, H. Hashimoto, K. Tani, S. Haner, H. Chatteijee, S. S. Structure-cytotoxic activity relationships of simple hydroxylated coumarins. Anticancer Res. 2003, 23, 3243-3246. Kawaii, S. Tomono, Y Ogawa, K. Suginra, M. Yano, M. Yoshizawa, Y. The antiproliferative effect of coumarins on several cancer cell lines. Anticancer Res. 2001, 21,917-923. 

Synthesis and Anticancer Activity of Some Novel 1,3,5-Trisubstituted pyrazolines using MDA-MB-231 and Hep-G2 cancer cell lines... 

Another promising development is the enantioselective hydrolysis of various racemic xenobiotic esters in healthy and cancerous rat liver cell lines [22], This has led to the design of anticancer prodrugs selectively activated by cancerous cell lines. 

The DKPs cyclo(His-Ala) and cyclo(His-Gly) proved to have promising anticancer activity comparable with that observed for cisplatin. Cyclo(His-Ala) in particular demonstrated an ability to inhibit tumor growth in HT-29, HeLa, and MCF-7 cancer cell lines. Cyclo(His-Gly) however, only had a marked effect on MCF-7 carcinoma cells at a concentration of 100 pmol 1. Both DKPs at a concentration of 0.5 mmolwere effective against two of the three Gram-positive bacteria, that is, Bacillus and S. aureus. Cycfo(His-Gfy) was more effective against Klebsiella pneumoniae than cyclo(His-Ala). Cyclo(His-Afa) and cycfo(His-Gfy) inhibited the growth of C. albicans by 66.3 and 47%, respectively. 

In 2003, the group of Banik has assayed some 2-azetidinones against nine human cancer cell lines as a measure of cytotoxicity [86]. Structure-activity studies have revealed that A-chrysenyl- and A-phenantrenyl-3-acetoxy-4-aryl-2-azetidinones (Fig. 46), respectively, have potent anticancer activity. The comparable /V-anthra-cenyl, A-pyrenyl, and A -naphthalenyl derivatives became inactive. It is evident that the minimal structural requirement of the aromatic moiety for cytotoxicity is at least three aromatic rings in an angular configuration. The presence of the acetoxy group at the C-3 position of the (3-lactams has proved to be obligatory for their antitumor activity [86]. 

Several reports have described the anticancer activity of curcumin in a variety of cancer cell lines. In vitro studies have established the activity for curcumin against breast, gastric, hepatic, pancreatic, colorectal, urinary bladder, kidney, prostate, cervical, ovarian, uterine, lung, oral, thymic, and skin cancers. Besides these cancer types, curcumin has shown in vitro therapeutic efficacy against hematological cancers including leukemia, lymphoma, and multiple myeloma. One of our early studies established that the antiproliferative effect of curcumin in human breast cancer cell lines, including hormone-dependent, hormone-independent,... 

Paclitaxel, camptothecin, vincristine, vinblastine, and other compounds currently under development as potential anticancer drugs (i.e., the bryostatins isolated from marine dinoflagellates) were discovered through a broad-based screening program to identify, using a whole-cell inhibition assay, natural products that are active against a battery of representative cancer cell lines. 

Genistein has been considered the primary anticancer constituent in soy, based on putative in vitro activities that include its ability to inhibit topoisomerase I and II activity, inhibit protein tyrosine phosphorylation, induce differentiation of cancer cell lines, and act as an estrogen agonist. 

Rhenium tricarbonyl complexes containing substituted cyclopentadi-enyl and bis diphenylphosphine ligands also were investigated as anticancer agents. The antiproliferative effects on breast cancer of complex A shown in Fig. 23 were examined relative to the known active metabolite, 4-hydroxy tamoxifen, and found to have a similar effect [107]. The cytotoxicity of five rhenium tricarbonyl bis-diphenylphosphine complexes B shown in Fig. 23 was examined for 18 different human cancer cell lines. The tests showed that all the complexes were active against specific tumor cell lines, especially a line of breast and uterine cancer [108]. 

Moebus VJ, Stein R, Kieback DG, Runnebaum IB, Sass G, Kreienberg R (1997) Antitumor activity of new organometallic compounds in human ovarian cancer cell lines and comparison to platin derivatives. Anticancer Res 17 815-821... 

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