California Proposition

Proposition 65 requires private employers to post warnings for persons handling carcinogenic compounds, and restricts all discharges of carcinogenic compounds. This is a new law that at present does not affect public institutions. However, state legislation is pending that will require public institutions to comply. 

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Passed in 1986 by the voters of California, Proposition 65 requires the Governor to publish, at least annually, a list of chemicals known to the state to cause cancer or reproductive toxicity . 

California Proposition 65 is the State s Safe Drinking Water and Toxic Enforcement Act of 1986. The purpose of the regulation is to prevent contamination of drinking water and to advise the public of any chemicals in products that are known to the state to cause cancer or reproductive toxicity.The governor of California is required to revise and republish the list of chemicals at least once a year. A Scientific Advisory Panel recommends additions to the list periodically. These additions are reviewed at a public hearing, may be incorporated in the official list, and go into... 

Heavy metal contamination of excipients is a concern, especially for sugars, phosphate, and citrate. Several rules have been proposed or established. For example, the EP sets a limit of nmt 1 ppm of nickel in polyols. California Proposition 65 specifies a limif of nmt 0.5 pg of lead per day per product. Similarly, the FDA has proposed a guideline that would limit the aluminum content for all EVPs used in TPN therapy to 25 pg/L. Furthermore, it requires that the maximum level of aluminum in SVPs intended to be added to EVPs and pharmacy bulk packages, at expiration date, be stated on the immediate container label. 

The Cannabis Buyers Club was the best known of such establishments, but it is not alone. Similar clubs exist overtly or covertly in cities and towns throughout the United States. The extent to which these clubs remain open is uncertain. The Cannabis Buyers Club was afforded a bit more security by the 1996 passage of California Proposition 215, which permitted use of marijuana for medicinal purposes. But more recently, in 2002, a federal injunction issued in California halted—at least temporarily—distribution of marijuana at this and other such clubs. Stay tuned for future developments on the state and national levels. 

Dibenz[(3, ] anthracene is listed as an International Agency for Research on Cancer 2A confirmed animal carcinogen and is listed as a California Proposition 65 carcinogen. 

RTECS CLASS OF COMPOUND Tumorigen Mutagen Reproductive Effector. Acute Oral Toxicity (LD50) 2330 mg/kg [Rat]. Acute Dermal Toxicity (LD50) 6700 mg/kg [Rat], Lowest Published Toxic Oral Dose (TDLo) 68250 mg/kg/91D-C [Rat], State of California (Proposition 65) as known to cause reproductive toxicity. 

Not listed as a carcinogen by IARC, NTP, ACGIF1 or OSHA. Also not listed on California Proposition 65. 

Ph some chemical research projects to address environmentally-related concerns of the fertilizer industry in the United States (7). In the United States, California Proposition ... 

Toxicology Exposure is by inhalation and by ingestion, with low level acute toxicity [22]. DBP was added to the California Proposition 65 (1986) List of Suspected Teratogens in November 2006. 

Regulatory Approval The drug master file, DMF-1578, has been established for Aclar films. Regarding the US FDA, Aclar films are made from resins that comply with 21 CFR 177.1380. With respect to Europe, Aclar films are made from monomers on the positive list of starting substances contained in the EC directive 90/128/EEC. Aclar films comply with many other regulatory requirements (CONEG and EU heavy metal limitations, California Proposition 65, etc.).[ ... 

States like California that have severe water shortage problems have taken drastic steps to protect their ground- and surface water. In California, Proposition 65, the Safe Drinking Water and Toxic Enforcement Act of 1986, requires the yearly update of a list of chemicals known to the state to cause cancer, birth defects, or other reproductive harm. Discharge of these chemicals into any water that might become a drinking water supply is prohibited, and violation of this prohibition may incur financial penalties. 

California Proposition 65. Formally known as the California Safe Drinking Water and Toxic Enforcement Act, that establishes two lists, one of which contains compounds known to the state to cause cancer, while the other list contains compounds known to be fetotoxic. 

Use of any drug, except when administered to a driver by, or imder the instructions of, a licensed medical practitioner, who has advised the driver that the substance will not affect the driver s ability to safely operate a commercial motor vehicle. (The use of marijuana under California Proposition 215 or the use of any Schedule I drug under Arizona Proposition 200 is not a legitimate medical explanation. Under federal law, the use of marijuana or any Schedule I drug does not have a legitimate medical use in the United States.) ... 

California Proposition 65 requires a clear and reasonable warning label for all products sold in the state of California containing one or more chemicals known to the state to cause cancer or reproductive toxicity. Labeling requirements are dependent on consumer exposure to the chemical (measured in micrograms (pg/day) not the concentration in the product. To comply with the law, manufacturers must either ensure that consumer exposure to regulated chemicals in their products do not exceed the established safe harbor levels or label their products. 

US - California Proposition 65 - Carcinogens Reproductive Toxicity (CRT) Listed substance... 

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