Calcium phosphates bioactive glass

Izquierdo-Barba, I., Jansson, K., Garcia, A., Arcos, D., Vallet-Regi, M., and Eden, M. (2011) Solid-state 31P and 1H NMR investigations of amorphous and crystalline calcium phosphates grown biomimetically from a mesoporous bioactive glass. J. Phys. Chem., 115 (42), 20572 -20582. 

Development of nano-structured alumina and zirconia ceramics and composites as well as nano-structured calcium phosphate ceramics and porous bioactive glasses, possibly as composites with organic constituents, will provide desired properties for bone substitution and tissue engineering for the next 20 years (Chevalier and Gremillard, 2009). 

Ceramics used in fabricating implants can be classified as nonabsorbable (relatively inert), bioactive or surface reactive (semi-inert) [Hench, 1991,1993] and biodegradable or resorbable (non-inert) [Hentrich et al., 1971 Graves et al., 1972]. Alumina, zirconia, silicone nitrides, and carbons are inert bioceramics. Certain glass ceramics and dense hydroxyapatites are semi-inert (bioreactive) and calcium phosphates and calcium aluminates are resorbable ceramics [Park and Lakes, 1992]. 

Yamamuro, T., Hench, L.L., and Wilson, J. (Eds.) (1990) Handbook of Bioactive Ceramics, Volume I Bioactive Glasses and Glass Ceramics, Volume II Calcium Phosphate and Hydroxylapatite Ceramics, CRC Press, Boca Raton, FL. A collection of articles on bioactive and resorbable bioceramics. 

The approach of making porous composites of P(3HB-co-3HV) with sol-gel bioactive glass (SGBG) and calcium phosphate-loaded collagen (CaP-Gelfix) foams have been tried for bone-tissue engineering. It was found to be useful since it showed formation of a HA layer on the surface of P(3HB-co-3HV)/SGBG... 

In another study, Yao et al. [30], reported on the optimal synthesis parameters and the kinetics of formation of calcium phosphate layer at the surface of PLGA/30 wt% bioactive glass porous composites. The porous structure supported marrow stromal cells (MSC) proliferation and promoted MSC differentiation into osteoblast phenotype cells. The porous composite was found to be bioactive and demonstrated a significant potential as a bone substitute. 

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