Calcium phosphate bone cements

Caleium phosphate cements (CPCs) have been investigated extensively as injectable bone replacement biomaterials due to their similar chemical composition to the mineral component of bone. A Umitation of CPCs is their brittle mechanical properties and slow degradation in vivo Therefore, enhancing the mechanical properties, injectability, and rate of cellular infiltration and remodeling of CPCs while preserving their favorable biocompatibility is an important and active area of research. While ceramic biomaterials are discussed in greater detail in Chapter 2, the biocompatibihty of conventional CPCs, as well as the implications of recent advancements on the biocompatibility of these biomaterials, will be reviewed in this chapter. 

CPCs are nontoxic to cells, biocompatible, and osteoconductive. Furthermore, CPCs are biologically active such that they remodel and incorporate in host bone, and thus do not induce a foreign-body response.These biomaterials set at a physiological pH with minimal reaction exotherm, and do not release toxic monomers or solvents.There are two primary classes of CPCs (a) 

Macropores 50 p,m are essential for promoting ingrowth of new bone into the In order to preserve the excellent biocompatibiUty of CPCs, 

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