Calcium hawthorn

Abrams, S. A., Griffin, I. J., Davila, P. M., and Hawthorne, K. M. (2003). Calcium absorption is similar from milk and two types of fortified orange juice at high intake levels. JBMR 18, Abst. S104. 

Abrams, A.S., Griffin, I.J., Hawthorne, K.M., Liang, L., Gunn, S.K., Darlington, G., and Ellis, K.J., A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents, Am. J. Clin. Nutr., 82, 471 —476, 2005. 

Various h bs and supplements such as hawthorn extracts garlic, onion, ginkgo biloba, vitamin and aspirin, maybe used by herbalists for hypertension. Although these sub ances may lo w blood pressure in some individuals their use is not recommended because the fect is ight and usually too gentle to affect mod ate to sev e hypertension. Howev, several studies have demonstrated that hypertensive patients may benefit from daily doses of calcium (800 mg) or magnesium (300 mg). Patients should consult the primary health care provid before taking any h bal remedy. 

A preliminary human study indicated a lack of interaction of an extract of dried flowering tops of hawthorn with low-dose insulin, metformin, gliclazide, ACE inhibitors, calcium channel blockers, 3-blockers, and diuretics (Walker et al. 2006). 

In a randomized trial of type 2 diabetes patients taking prescribed drugs, administration of 1200 mg daily of a 3 1 hawthorn leaf and flower extract for 16 weeks resulted in a moderate decrease in blood pressure with no adverse interactions reported. Prescription drugs being taken by the trial participants were hypoglycemic medications (low-dose insulin, metformin, gliclazide, and "others") and hypotensive medication (ACE inhibitors, calcium channel blockers, P blockers, diuretics, and "others") (Walker et al. 2006). 

Abrams SA, Griffin IJ, Hawthorne KM, EUis KJ. Effect of prebiotic supplementation and calcium intake on body mass Index.J Pediatr 2007 151(3) 293-8. 

Abrams SA, Hawthorne KM, Aliu O, Hicks PD, Chen Z, Griffin IJ. An inulin-type fructan enhances calcium absorption primarily via an effect on colonic absorption in humans. J Nutr. 2007 137 2208-2212. 

Hawthorn M, Ferrante J, Luchowski E, Rutledge A, Wei XY, Triggle DJ (1988) The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations. Aliment Pharmacol Ther 2 101... 

A 10 min period of electrical stimulation in the presence of Pi led to increased labelling of synaptosomal phosphatidate (Bleasdale Hawthorne, 1975) but no consistent, increase in phosphatidylinositol specific radioactivity. The labelling of ATP was unaffected. When sub-synaptosomal membrane fractions were prepared, the increased phosphatidate labelling was seen to be associated with the synaptic vesicle fraction, as in the acetylcholine experiments. Further work (Hawthorne Bleasdale, 1975) showed that electrical stimulation only increased the labelling of phosphatidate in the vesicle fraction when the medium contained calcium ions. This and the time course of labelling (changes seen 2 min after the onset of stimulation) suggest that the metabolism of phosphatidate is closely associated with the process of transmitter release. 

Abrams SA, Hawthorne KM, Chen Z. Supplementation with 1000 lU vitamin D/d leads to parathyroid hormone suppression, but not increased fractional calcium absorption, in 4-8-y-old children a double-blind randomized controlled trial. Am J din Nutr January 2013 97(l) 217-23. 

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