C-signal transduction

The PLCy and Protein Kinase C Signal-Transduction Pathway.251... 

Grant S, Jarvis DW (1996) Modulation of drug-induced apoptosis by interruption of protein kinase C signal transduction pathway a new therapeutic strategy. Clin Cancer Res 2 1915-1920... 

McNamara R. K., Ostrander M., Abplanalp W., Richtand N. M., Benoit S. C., and Clegg D. J. (2006). Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids Implications for the pathophysiology and treatment of recurrent neuropsychiatric illness. Prostaglandins Leukot. Essent. Fatty Acids 75 237-257. 

Figure 27.14. Activation of intracellular signaling pathways and cytokine gene expression by air pollution particles containing transition metals and endotoxin. (From Walters, D. M., and Bonner, J. C. Signal transduction and cytokine expression in particulate matter (PM)-induced airway remodeling. In Foster, W. M., and Costa, D. L. (Eds.). Air Pollutants and the Respiratory Tract, 2nd edition, Taylor Francis, New York, 2005, pp. 233-258.)...

Calcitonin Neither deficiency nor excess of calcitonin is known to have any pathological effects. Plasma calcitonin is increased in the medullary carcinoma of the thyroid. Binds to cell-surface receptors in bone and kidney, increasing intracellular cAMP may also function by activation of phospholipase C signal transduction pathway, decreases Ca " " release from bone and stimulate Ca " " and phosphate excretion in kidneys, generally antagonistic to PTH. 

C signal transduction pathway. Secretion of calcitonin is stimulated by hypercalcemia but the effect of the hormone on calcium transport appears to be secondary to increased phosphate uptake by target cells. The number and activity of osteoclasts are decreased, and urinary excretion of hy-droxyproline is decreased, Calcitonin may also inhibit release of calcium from the extracellular fluid calcium pool, but it increases calcium and phosphate excretion by renal tubules. Some tubular cells respond to calcitonin, PTH, and vasopressin, while others respond only to one or two of these hormones. In general, the actions of calcitonin in kidney and in bone are antagonistic to those of PTH. Calcitonin decreases secretion of gastrin and of gastric acid, and inhibits bile flow. 

Li L, Eto M, Lee MR, Mortia F, Yazawa M, Kitazawa T (1998) Possible involvement of the novel CPI-17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle. J Physiol Lond 508 871-881 Liu G, Liu X, Rao K, Jiang H, Stephens NL (1996) Increased myosin light chain kinase content in sensitized canine saphenous vein. J Appl Physiol 80 665-669... 

C-factor sensor - CsgA protein on cell surface Figure 11. The C-sIgnal transduction pathway. Modified (with permission] from [37]. 

Recent reports suggest the existence in plant cells of all of the main components of this IP3/Ca+ and DAG/protein kinase C signal transduction system. A protein kinase C-like enzyme was partially purified from zucchini [17] and wheat cells [14]. It was also recently reported that IP3/Ca and DAG/protein kinase C pathways are involved in carrot cell response to an elicitor [9]. 

Heldin C. Signal transduction multiple pathways, multiple options for therapy. Stem Cells 2001 19(4) 295 303. 

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